In vivo and in vitro expression of myeloid antigens on B-lineage acute lymphoblastic leukemia cells

Junichi Hara, Keisei Kawa-Ha, Keiko Yumura-Yagi, Hiroki Kurahashi, Akio Tawa, Shigehiko Ishihara, Masami Inoue, Norihide Murayama, Shintaro Okada

研究成果: Article

10 引用 (Scopus)

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The expression of myeloid antigens has been extensively examined using two-color analysis in 43 children with B-lineage acute lymphoblastic leukemia (ALL). On pre-culture cells, CD33 expression was frequently observed in CD19+, CD10- B-precursor ALL, and CD14 was expressed only on the cells from B-precursor ALL expressing CD19, CD10 and CD20, and B-ALL. After 2 or 3 days of culture without TPA, CD13 emerged on the cells from 21 of 29 patients irrespective of the presence or the absence of fetal calf serum in the culture. Of four patients with CD10+ B-precursor ALL, which showed no expression of CD13 after culture, two had T-cell associated antigens. Whereas the addition of TPA to the culture enhanced the expression of CD13 on the cells from acute non-lymphocytic leukemia (ANLL), TPA reduced the expression of this antigen on B-precursor cells. These findings suggest that the regulatory mechanism of CD13 expression may be different between B-precursor ALL and ANLL. Co-culture with cycloheximide mostly abrogated the induction of CD13, suggesting that CD13 expression was mainly dependent on de novo protein synthesis.

元の言語English
ページ(範囲)19-25
ページ数7
ジャーナルLeukemia
5
発行部数1
出版物ステータスPublished - 01-1991
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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    Hara, J., Kawa-Ha, K., Yumura-Yagi, K., Kurahashi, H., Tawa, A., Ishihara, S., Inoue, M., Murayama, N., & Okada, S. (1991). In vivo and in vitro expression of myeloid antigens on B-lineage acute lymphoblastic leukemia cells. Leukemia, 5(1), 19-25.