TY - JOUR
T1 - In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet
AU - Kawai, K.
AU - Beppu, H.
AU - Shimpo, K.
AU - Chihara, T.
AU - Yamamoto, N.
AU - Nagatsu, T.
AU - Ueda, H.
AU - Yamada, Y.
PY - 1998/5
Y1 - 1998/5
N2 - Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30% freeze-dried Kidachi aloe for 10 days showed a 70% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.
AB - Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30% freeze-dried Kidachi aloe for 10 days showed a 70% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.
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U2 - 10.1002/(SICI)1099-1573(199805)12:3<178::AID-PTR218>3.0.CO;2-F
DO - 10.1002/(SICI)1099-1573(199805)12:3<178::AID-PTR218>3.0.CO;2-F
M3 - Article
AN - SCOPUS:0031896750
VL - 12
SP - 178
EP - 182
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 3
ER -