In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet

K. Kawai, H. Beppu, K. Shimpo, T. Chihara, N. Yamamoto, T. Nagatsu, H. Ueda, Y. Yamada

研究成果: Article

17 引用 (Scopus)

抄録

Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30% freeze-dried Kidachi aloe for 10 days showed a 70% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.

元の言語English
ページ(範囲)178-182
ページ数5
ジャーナルPhytotherapy Research
12
発行部数3
DOI
出版物ステータスPublished - 05-1998

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Tinea Pedis
Aloe
Foot
Guinea Pigs
Trichophyton
Tinea
latoconazole
Molecular Weight
Antifungal Agents
Growth
Head

All Science Journal Classification (ASJC) codes

  • Pharmacology

これを引用

Kawai, K. ; Beppu, H. ; Shimpo, K. ; Chihara, T. ; Yamamoto, N. ; Nagatsu, T. ; Ueda, H. ; Yamada, Y. / In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet. :: Phytotherapy Research. 1998 ; 巻 12, 番号 3. pp. 178-182.
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abstract = "Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30{\%} freeze-dried Kidachi aloe for 10 days showed a 70{\%} growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.",
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In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet. / Kawai, K.; Beppu, H.; Shimpo, K.; Chihara, T.; Yamamoto, N.; Nagatsu, T.; Ueda, H.; Yamada, Y.

:: Phytotherapy Research, 巻 12, 番号 3, 05.1998, p. 178-182.

研究成果: Article

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AU - Kawai, K.

AU - Beppu, H.

AU - Shimpo, K.

AU - Chihara, T.

AU - Yamamoto, N.

AU - Nagatsu, T.

AU - Ueda, H.

AU - Yamada, Y.

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