In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam

Mengyun Yin, Guoping Hu, Zhen Shen, Chengli Fang, Xuefei Zhang, Dan Li, Yohei Doi, Yu Zhang, Minggui Wang, Qinglan Guoa

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Here, we report a novel narrow-spectrum β-lactamase CTX-M-215 identified in an Escherichia coli clinical isolate in China and conferring high-level resistance to mecillinam but not to cefotaxime. CTX-M-215 differed from CTX-M-125, a CTX-M extended-spectrum β-lactamase (ESBL), by an N132D substitution, which decreased hydrolytic activities toward penicillins and cephalosporins except for mecillinam. High similarity was observed between CTX-M-215- and CTX-M-125-bearing plasmids, carried by different isolates in the same patient, indicating in vivo evolution of CTX-M-215 from CTX-M-125.

本文言語English
論文番号e00562
ジャーナルAntimicrobial agents and chemotherapy
64
11
DOI
出版ステータスPublished - 10-2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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