In vivo histological diagnosis for gastric cancer using endocytoscopy

Issei Tsurudome, Ryoji Miyahara, Kohei Funasaka, Kazuhiro Furukawa, Masanobu Matsushita, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Osamu Watanabe, Masato Nakaguro, Akira Satou, Yoshiki Hirooka, Hidemi Goto

研究成果: Article

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Aim To examine usefulness of virtual biopsy using endocytoscopy by comparing the in vivo endocytoscopic and histopathological images of gastric cancers. METHODS Endocytoscopy was performed in 30 patients with early gastric cancer. Of these, 26 patients showed well differentiated adenocarcinomas, while 4 patients showed poorly differentiated adenocarcinomas (including one signet ring cell carcinoma). Cancerous and non-cancerous areas were observed after double staining with 0.05% crystal violet and 0.1% methylene blue. The endocytoscopic images obtained were evaluated by an expert endoscopist and an expert pathologist without knowledge of patient clinical data, and endocytoscopic and histopathological diagnoses were compared. RESULTS The endocytoscopic images of the cancerous area were assessed as evaluable in 25 (83.3%) and 27 (90%) patients by endoscopist A and pathologist B, respectively, and those of the non-cancerous area as evaluable in 28 (93.3%) and 23 (76.7%) patients by the endoscopist and pathologist, respectively. The sensitivity, specifcity, and diagnostic accuracy of gastric cancer diagnosis using evaluable endocytoscopic images were 88.0% and 92.9%, and 90.6% by endoscopist A, and 88.9% and 91.3%, and 90.0% by pathologist B, respectively. Evaluation of the diagnostic concordance rate between the endoscopist and the pathologist by inter-observer agreement calculation revealed no significant difference between the two observers. The inter-observer agreement (-value) for endocytoscopic diagnosis was 0.745. CONCLUSION Endocytoscopy is useful for the differentiation of cancerous from non-cancerous gastric mucosa, making it a promising tool for virtual biopsy.

元の言語English
ページ(範囲)6894-6901
ページ数8
ジャーナルWorld Journal of Gastroenterology
23
発行部数37
DOI
出版物ステータスPublished - 07-10-2017

All Science Journal Classification (ASJC) codes

  • Gastroenterology

フィンガープリント In vivo histological diagnosis for gastric cancer using endocytoscopy' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Tsurudome, I., Miyahara, R., Funasaka, K., Furukawa, K., Matsushita, M., Yamamura, T., Ishikawa, T., Ohno, E., Nakamura, M., Kawashima, H., Watanabe, O., Nakaguro, M., Satou, A., Hirooka, Y., & Goto, H. (2017). In vivo histological diagnosis for gastric cancer using endocytoscopy. World Journal of Gastroenterology, 23(37), 6894-6901. https://doi.org/10.3748/wjg.v23.i37.6894