In vivo imaging of neuroinflammation in Alzheimer's disease

Makoto Higuchi, Bin Ji, Jun Maeda, Naruhiko Sahara, Tetsuya Suhara

研究成果: ジャーナルへの寄稿総説査読

5 被引用数 (Scopus)

抄録

Diverse neurological dementias show neuropathological features, such as deposition of abnormal protein aggregates, as exemplified by accumulation of amyloid-beta peptide and tau proteins in Alzheimer's disease. These pathological changes are accompanied by activation of inflammatory microglia and astrocytes, which act on neurons either deleteriously or protectively. Several molecular markers including 18-kDa translocator protein are known to be upregulated in aggressive microglia exerting neurotoxicity, and in vivo visualization of these components potentially contributes to assessments of the disease severity. Meanwhile, biological indicators for other microglial and astrocytic phenotypes are yet to be identified. Inflammatory microgliosis has also been found to have bidirectional mechanistic links to amyloid-beta peptide and tau pathologies, and neurodegeneration, supporting the view that modifications of degenerative dementias will be enabled by optimizing immunotherapeutic approaches to neuroinflammation with the aid of imaging modalities targeting specific glial phenotypes.

本文言語英語
ページ(範囲)139-144
ページ数6
ジャーナルClinical and Experimental Neuroimmunology
7
2
DOI
出版ステータス出版済み - 01-05-2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(その他)
  • 免疫学
  • 免疫学および微生物学(その他)
  • 臨床神経学

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