In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

Misa Suzuki-Anekoji; Atsushi Suzuki; Sz Wei Wu; Kiyohiko Angata; Keith K. Murai; Kazuhiro Sugihara; Tomoya O. Akama; Kay Hooi Khoo; Jun Nakayama; Michiko N. Fukuda; Minoru Fukuda

doi:10.1074/jbc.M112.433474

In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

Misa Suzuki-Anekoji
, Atsushi Suzuki
, Sz Wei Wu
, Kiyohiko Angata
, Keith K. Murai
, Kazuhiro Sugihara
, Tomoya O. Akama
, Kay Hooi Khoo
, Jun Nakayama
, Michiko N. Fukuda
, Minoru Fukuda

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

抄録

Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

本文言語	英語
ページ（範囲）	5007-5016
ページ数	10
ジャーナル	Journal of Biological Chemistry
巻	288
号	7
DOI	https://doi.org/10.1074/jbc.M112.433474
出版ステータス	出版済み - 15-02-2013
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
分子生物学
細胞生物学

文献へのアクセス

10.1074/jbc.M112.433474

他のファイルとリンク

引用スタイル

@article{38a5bbc7c1a844c1b98cf80904003754,

title = "In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse",

abstract = "Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.",

author = "Misa Suzuki-Anekoji and Atsushi Suzuki and Wu, \{Sz Wei\} and Kiyohiko Angata and Murai, \{Keith K.\} and Kazuhiro Sugihara and Akama, \{Tomoya O.\} and Khoo, \{Kay Hooi\} and Jun Nakayama and Fukuda, \{Michiko N.\} and Minoru Fukuda",

year = "2013",

month = feb,

day = "15",

doi = "10.1074/jbc.M112.433474",

language = "English",

volume = "288",

pages = "5007--5016",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "7",

}

TY - JOUR

T1 - In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

AU - Suzuki-Anekoji, Misa

AU - Suzuki, Atsushi

AU - Wu, Sz Wei

AU - Angata, Kiyohiko

AU - Murai, Keith K.

AU - Sugihara, Kazuhiro

AU - Akama, Tomoya O.

AU - Khoo, Kay Hooi

AU - Nakayama, Jun

AU - Fukuda, Michiko N.

AU - Fukuda, Minoru

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

AB - Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

UR - https://www.scopus.com/pages/publications/84874051251

UR - https://www.scopus.com/pages/publications/84874051251#tab=citedBy

U2 - 10.1074/jbc.M112.433474

DO - 10.1074/jbc.M112.433474

M3 - Article

C2 - 23269668

AN - SCOPUS:84874051251

SN - 0021-9258

VL - 288

SP - 5007

EP - 5016

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

抄録

All Science Journal Classification (ASJC) codes

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル