Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma

Ikuo Yana, Tsutomu Nakamura, Eisei Shin, Katsu Karakawa, Hiroki Kurahashi, Yoshihiro Kurita, Tetsuro Kobayashi, Takesada Mori, Isamu Nishisho, Shin‐ichiro ‐i Takai

研究成果: ジャーナルへの寄稿学術論文査読

31 被引用数 (Scopus)

抄録

A polymerase chain reaction (PCR)‐mediated RNase protection analysis was performed to detect subtle genetic alterations of p53 in medullary thyroid carcinoma (MTC) and pheochromocytoma. None of the 30 pheochromocytomas showed abnormal RNase protection patterns. Only one of 32 MTCs showed an abnormal pattern, and subsequent DNA sequencing of the PCR product revealed that it had a G to C transversion in codon 49 that resulted in a change from aspartic acid to histidine. However, this was a sporadic MTC with no specific clinicopathological characteristics. On the basis of a previous report that genes on chromosome 17p were not deleted in MTCs and were relatively infrequently deleted in pheochromocytomas, our results suggest that the p53 gene is not involved in tumorigenesis of MTC or pheochromocytoma.

本文言語英語
ページ(範囲)1113-1116
ページ数4
ジャーナルJapanese Journal of Cancer Research
83
11
DOI
出版ステータス出版済み - 11-1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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