Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma

Ikuo Yana, Tsutomu Nakamura, Eisei Shin, Katsu Karakawa, Hiroki Kurahashi, Yoshihiro Kurita, Tetsuro Kobayashi, Takesada Mori, Isamu Nishisho, Shin‐ichiro ‐i Takai

研究成果: Article

28 引用 (Scopus)

抄録

A polymerase chain reaction (PCR)‐mediated RNase protection analysis was performed to detect subtle genetic alterations of p53 in medullary thyroid carcinoma (MTC) and pheochromocytoma. None of the 30 pheochromocytomas showed abnormal RNase protection patterns. Only one of 32 MTCs showed an abnormal pattern, and subsequent DNA sequencing of the PCR product revealed that it had a G to C transversion in codon 49 that resulted in a change from aspartic acid to histidine. However, this was a sporadic MTC with no specific clinicopathological characteristics. On the basis of a previous report that genes on chromosome 17p were not deleted in MTCs and were relatively infrequently deleted in pheochromocytomas, our results suggest that the p53 gene is not involved in tumorigenesis of MTC or pheochromocytoma.

元の言語English
ページ(範囲)1113-1116
ページ数4
ジャーナルJapanese Journal of Cancer Research
83
発行部数11
DOI
出版物ステータスPublished - 01-01-1992
外部発表Yes

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p53 Genes
Pheochromocytoma
Carcinogenesis
Ribonucleases
Polymerase Chain Reaction
DNA-Directed DNA Polymerase
DNA Sequence Analysis
Histidine
Aspartic Acid
Codon
Chromosomes
Medullary Thyroid cancer
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Yana, Ikuo ; Nakamura, Tsutomu ; Shin, Eisei ; Karakawa, Katsu ; Kurahashi, Hiroki ; Kurita, Yoshihiro ; Kobayashi, Tetsuro ; Mori, Takesada ; Nishisho, Isamu ; Takai, Shin‐ichiro ‐i. / Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma. :: Japanese Journal of Cancer Research. 1992 ; 巻 83, 番号 11. pp. 1113-1116.
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abstract = "A polymerase chain reaction (PCR)‐mediated RNase protection analysis was performed to detect subtle genetic alterations of p53 in medullary thyroid carcinoma (MTC) and pheochromocytoma. None of the 30 pheochromocytomas showed abnormal RNase protection patterns. Only one of 32 MTCs showed an abnormal pattern, and subsequent DNA sequencing of the PCR product revealed that it had a G to C transversion in codon 49 that resulted in a change from aspartic acid to histidine. However, this was a sporadic MTC with no specific clinicopathological characteristics. On the basis of a previous report that genes on chromosome 17p were not deleted in MTCs and were relatively infrequently deleted in pheochromocytomas, our results suggest that the p53 gene is not involved in tumorigenesis of MTC or pheochromocytoma.",
author = "Ikuo Yana and Tsutomu Nakamura and Eisei Shin and Katsu Karakawa and Hiroki Kurahashi and Yoshihiro Kurita and Tetsuro Kobayashi and Takesada Mori and Isamu Nishisho and Takai, {Shin‐ichiro ‐i}",
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Yana, I, Nakamura, T, Shin, E, Karakawa, K, Kurahashi, H, Kurita, Y, Kobayashi, T, Mori, T, Nishisho, I & Takai, S 1992, 'Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma', Japanese Journal of Cancer Research, 巻. 83, 番号 11, pp. 1113-1116. https://doi.org/10.1111/j.1349-7006.1992.tb02730.x

Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma. / Yana, Ikuo; Nakamura, Tsutomu; Shin, Eisei; Karakawa, Katsu; Kurahashi, Hiroki; Kurita, Yoshihiro; Kobayashi, Tetsuro; Mori, Takesada; Nishisho, Isamu; Takai, Shin‐ichiro ‐i.

:: Japanese Journal of Cancer Research, 巻 83, 番号 11, 01.01.1992, p. 1113-1116.

研究成果: Article

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AU - Karakawa, Katsu

AU - Kurahashi, Hiroki

AU - Kurita, Yoshihiro

AU - Kobayashi, Tetsuro

AU - Mori, Takesada

AU - Nishisho, Isamu

AU - Takai, Shin‐ichiro ‐i

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