Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan

研究成果: ジャーナルへの寄稿学術論文査読

抄録

An increase in the number of herpes zoster patients has been reported since universal varicella immunization was introduced, perhaps because of reduced opportunities for varicella patients to experience the natural booster effect caused by reexposure. We investigated recent trends of varicella zoster virus (VZV)–related central nervous system (CNS) infections at a university hospital in Japan. We enrolled patients with suspected CNS infection during 2013–2022 and tested cerebrospinal fluid samples by real-time PCR for DNA from 7 human herpesviruses. VZV DNA was the most commonly detected in 62 (10.2%) of 615 patients. Kulldorff’s circular spatial scan statistics demonstrated a significant temporal cluster of patients with VZV-related CNS infections during 2019–2022 (p = 0.008). Among persons with such infections, the percentage with aseptic meningitis was significantly higher during 2019–2022 (86.8%), when the temporal cluster of cases occurred, than during 2013–2018 (50.0%) (p = 0.0029).

本文言語英語
ページ(範囲)2476-2482
ページ数7
ジャーナルEmerging Infectious Diseases
30
12
DOI
出版ステータス出版済み - 12-2024

All Science Journal Classification (ASJC) codes

  • 疫学
  • 微生物学(医療)
  • 感染症

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