TY - JOUR
T1 - Increase in muscle mass associated with the prebiotic effects of 1-kestose in super-elderly patients with sarcopenia
AU - Tominaga, Kentaro
AU - Tsuchiya, Atsunori
AU - Nakano, Oki
AU - Kuroki, Yasutoshi
AU - Oka, Kentaro
AU - Minemura, Ayaka
AU - Matsumoto, Asami
AU - Takahashi, Motomichi
AU - Kadota, Yoshihiro
AU - Tochio, Takumi
AU - Niwa, Yusuke
AU - Yoshida, Tomoaki
AU - Sato, Masatoshi
AU - Yokoo, Takeshi
AU - Hashimoto, Satoru
AU - Yokoyama, Junji
AU - Matsuzawa, Jun
AU - Fujimori, Katsuya
AU - Terai, Shuji
N1 - Publisher Copyright:
© 2021. BMFH Press.
PY - 2021
Y1 - 2021
N2 - Sarcopenia causes functional disorders and decreases the quality of life. Thus, it has attracted substantial attention in the aging modern world. Dysbiosis of the intestinal microbiota is associated with sarcopenia; however, it remains unclear whether prebiotics change the microbiota composition and result in the subsequent recovery of muscle atrophy in elderly patients with sarcopenia. This study aimed to assess the effects of prebiotics in super-elderly patients with sarcopenia. We analyzed the effects of 1-kestose on the changes in the intestinal microbiota and body composition using a next-generation sequencer and a multi-frequency bioimpedance analysis device. The Bifidobacterium longum population was significantly increased in the intestine after 1-kestose administration. In addition, in all six patients after 12 weeks of 1-kestose administration, the skeletal muscle mass index was greater, and the body fat percentage was lower. This is the first study to show that administration of a prebiotic increased the population of B. longum in the intestinal microbiota and caused recovery of muscle atrophy in super-elderly patients with sarcopenia.
AB - Sarcopenia causes functional disorders and decreases the quality of life. Thus, it has attracted substantial attention in the aging modern world. Dysbiosis of the intestinal microbiota is associated with sarcopenia; however, it remains unclear whether prebiotics change the microbiota composition and result in the subsequent recovery of muscle atrophy in elderly patients with sarcopenia. This study aimed to assess the effects of prebiotics in super-elderly patients with sarcopenia. We analyzed the effects of 1-kestose on the changes in the intestinal microbiota and body composition using a next-generation sequencer and a multi-frequency bioimpedance analysis device. The Bifidobacterium longum population was significantly increased in the intestine after 1-kestose administration. In addition, in all six patients after 12 weeks of 1-kestose administration, the skeletal muscle mass index was greater, and the body fat percentage was lower. This is the first study to show that administration of a prebiotic increased the population of B. longum in the intestinal microbiota and caused recovery of muscle atrophy in super-elderly patients with sarcopenia.
KW - 1-kestose
KW - Bifidobacterium longum
KW - intestinal microbiota
KW - prebiotics
KW - sarcopenia
UR - https://www.scopus.com/pages/publications/85111566247
UR - https://www.scopus.com/pages/publications/85111566247#tab=citedBy
U2 - 10.12938/bmfh.2020-063
DO - 10.12938/bmfh.2020-063
M3 - Article
AN - SCOPUS:85111566247
SN - 2186-6953
VL - 40
SP - 150
EP - 155
JO - Bioscience of Microbiota, Food and Health
JF - Bioscience of Microbiota, Food and Health
IS - 3
ER -