Increase in the Capability of Interleukin 2 Gene-Transduced Renal Cell Carcinoma Cells to Induce Cytotoxic Lymphocytes

Kyogo Itoh, Yasuiki Umezu, Tatsuo Morita, Dai Seito, Lazel B. Augustus, Hideyuki Saya, Kyogo Itoh, Masanobu Nakao, Motoko Sakata, Jiro Miyajima, Kazuhiro Masuoka, Hiroshi Matsui

研究成果: Article査読

2 被引用数 (Scopus)

抄録

The immunogenicity of human cancer cells transfected with interleukin 2 (IL-2) gene, a potent vaccine candidate, has not yet been fully investigated. Human renal cell carcinoma (RCC) cells transduced with human IL-2 gene (RCC-IL-2) were investigated in vitro for the capability to induce lymphokine-activated killer (LAK) or cytotoxic T lymphocyte (CTL) activity in peripheral blood mononuclear cells (PBMC) or tumor-infiltrating lymphocyte (TIL). The RCC-IL-2 cells stimulated PBMC to demonstrate LAK activity, and also stimulated autologous TILs to proliferate and exhibit cytotoxicity relatively restricted to autologous tumor cells. In contrast, both parental RCC and RCC transduced with neomycin gene alone failed to induce these activities. These results indicate that RCC-IL-2 cells are more potent than the other RCC cells with regard to inducing cytotoxic lymphocytes against autologous tumor cells.

本文言語English
ページ(範囲)53-63
ページ数11
ジャーナルThe Kurume Medical Journal
41
2
DOI
出版ステータスPublished - 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

フィンガープリント

「Increase in the Capability of Interleukin 2 Gene-Transduced Renal Cell Carcinoma Cells to Induce Cytotoxic Lymphocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル