Increase of transcriptional levels of egr-1 and nur77 genes due to both nicotine treatment and withdrawal in pheochromocytoma cells

N. Ichino, K. Yamada, K. Nishii, H. Sawada, T. Nagatsu, H. Ishiguro

研究成果: Article査読

15 被引用数 (Scopus)

抄録

The influence of nicotine on the expression of egr-1 and nur77 genes by nicotine treatment and withdrawal was assessed using PC12 cells. Nicotine treatment significantly increased the amount of mRNA for egr-1 and nur77 genes at 0.5h post-nicotine treatment in the PC12 cells. In addition, nicotine withdrawal also elevated transcriptional levels of egr-1 and nur77 genes in Northern blot analyses. Nicotine treatment (200 μM) was also found to significantly increase expressional levels of Egr-1 and Nur77 proteins at 0.5h post-nicotine treatment. In contrast, Egr-1 and Nur77 protein levels were dramatically decreased by nicotine withdrawal. These results suggest that expressional levels of Egr-1 and Nur77 proteins in neural cells may affect the transcriptional activity of late-response genes after nicotine withdrawal.

本文言語English
ページ(範囲)1015-1022
ページ数8
ジャーナルJournal of Neural Transmission
109
7-8
DOI
出版ステータスPublished - 23-07-2002

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生
  • 生物学的精神医学

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