TY - JOUR
T1 - Increased activity and intranuclear expression of phospholipase D2 in human renal cancer
AU - Zhao, Yutong
AU - Ehara, Hidetoshi
AU - Akao, Yukihiro
AU - Shamoto, Masayo
AU - Nakagawa, Yoshihito
AU - Banno, Yoshiko
AU - Deguchi, Takashi
AU - Ohishi, Nobuko
AU - Yagi, Kunio
AU - Nozawa, Yoshinori
N1 - Funding Information:
We thank Dr. Micheal Frohman for providing mPLD2 cDNA. This work was supported in part by a Grant-in-Aid for Scientific Research by the Ministry of Education, Science, Sports, and Culture of Japan, and by a Special Coordination Fund for Promoting Science and Technology from the Science and Technology Agency of Japan.
PY - 2000/11/11
Y1 - 2000/11/11
N2 - We examined the PLD activities of human renal cancers and found that the PLD2 activity was greatly elevated in almost all cases examined as compared with the adjacent normal region. Western blot analysis showed the increased levels of PLD2 protein, but the PLD1 was not discernible. The oleate-dependent PLD activity was very low but appeared to increase in most cases. Interestingly, the immunohistochemical observations indicated the high expression of PLD2 in the nuclei of clear carcinoma cells. This is the first demonstration which suggests the possible involvement of PLD2 in tumorigenesis of renal cancer. (C) 2000 Academic Press.
AB - We examined the PLD activities of human renal cancers and found that the PLD2 activity was greatly elevated in almost all cases examined as compared with the adjacent normal region. Western blot analysis showed the increased levels of PLD2 protein, but the PLD1 was not discernible. The oleate-dependent PLD activity was very low but appeared to increase in most cases. Interestingly, the immunohistochemical observations indicated the high expression of PLD2 in the nuclei of clear carcinoma cells. This is the first demonstration which suggests the possible involvement of PLD2 in tumorigenesis of renal cancer. (C) 2000 Academic Press.
UR - https://www.scopus.com/pages/publications/0034638599
UR - https://www.scopus.com/pages/publications/0034638599#tab=citedBy
U2 - 10.1006/bbrc.2000.3719
DO - 10.1006/bbrc.2000.3719
M3 - Article
C2 - 11185526
AN - SCOPUS:0034638599
SN - 0006-291X
VL - 278
SP - 140
EP - 143
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -
SDG 3 すべての人に健康と福祉を