Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder

Akio Kimura; Masao Takemura; Kuniaki Saito; Ginette Serrero; Nobuaki Yoshikura; Yuichi Hayashi; Takashi Inuzuka

doi:10.1016/j.jneuroim.2017.01.006

Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder

Akio Kimura
, Masao Takemura
, Kuniaki Saito
, Ginette Serrero
, Nobuaki Yoshikura
, Yuichi Hayashi
, Takashi Inuzuka

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

24 被引用数 (Scopus)

抄録

We examined progranulin (PGRN) levels in cerebrospinal fluid (CSF) samples during the acute phase in 15 patients with neuromyelitis optica spectrum disorders (NMOSD) and compared the results with those from 17 patients with multiple sclerosis (MS), 30 patients with other inflammatory neurological diseases (OIND), and 20 non-inflammatory controls (NIC). CSF PGRN levels of NMOSD patients were significantly higher than those of MS patients and NICs. These levels correlated with CSF interleukin-6 levels, CSF cell counts, CSF protein levels, improvements in the Expanded Disability Status Scale score, and affected total spinal cord lesion length in the NMOSD patients.

本文言語	英語
ページ（範囲）	175-181
ページ数	7
ジャーナル	Journal of Neuroimmunology
巻	305
DOI	https://doi.org/10.1016/j.jneuroim.2017.01.006
出版ステータス	出版済み - 15-04-2017
外部発表	はい

All Science Journal Classification (ASJC) codes

免疫アレルギー学
免疫学
神経学
臨床神経学

文献へのアクセス

10.1016/j.jneuroim.2017.01.006

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引用スタイル

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abstract = "We examined progranulin (PGRN) levels in cerebrospinal fluid (CSF) samples during the acute phase in 15 patients with neuromyelitis optica spectrum disorders (NMOSD) and compared the results with those from 17 patients with multiple sclerosis (MS), 30 patients with other inflammatory neurological diseases (OIND), and 20 non-inflammatory controls (NIC). CSF PGRN levels of NMOSD patients were significantly higher than those of MS patients and NICs. These levels correlated with CSF interleukin-6 levels, CSF cell counts, CSF protein levels, improvements in the Expanded Disability Status Scale score, and affected total spinal cord lesion length in the NMOSD patients.",

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AU - Hayashi, Yuichi

AU - Inuzuka, Takashi

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