Increased fearfulness of Fyn tyrosine kinase deficient mice

Tsuyoshi Miyakawa, Takeshi Yagi, Satoshi Watanabe, Hiroaki Niki

研究成果: Article査読

78 被引用数 (Scopus)

抄録

Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.

本文言語English
ページ(範囲)179-182
ページ数4
ジャーナルMolecular Brain Research
27
1
DOI
出版ステータスPublished - 11-1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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