TY - JOUR
T1 - Increased fearfulness of Fyn tyrosine kinase deficient mice
AU - Miyakawa, Tsuyoshi
AU - Yagi, Takeshi
AU - Watanabe, Satoshi
AU - Niki, Hiroaki
N1 - Funding Information:
supported in part by Grant-in-Aid for Cooperative Research 05301011 to H. Niki for 1993-1994 from the Japanese Ministry of Education, Science and Culture.
PY - 1994/11
Y1 - 1994/11
N2 - Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.
AB - Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.
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U2 - 10.1016/0169-328X(94)90201-1
DO - 10.1016/0169-328X(94)90201-1
M3 - Article
C2 - 7877449
AN - SCOPUS:0028113050
SN - 0169-328X
VL - 27
SP - 179
EP - 182
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1
ER -