Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury

Andrew R. Blight, Kuniaki Saito, Melvyn P. Heyes

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Products of inflammatory phagocytes are potential contributors to secondary pathology following spinal cord trauma. In the present study we quantified the levels of the neurotoxin and product of activated macrophages, quinolinic acid (QUIN), in the lower thoracic spinal cord of adult guinea pigs 5 days after brief compression injury. At the injured site (T13), elevations in tissue QUIN levels (> 10-fold) accompanied proportional increases in the activity of indoleamine-2,3 dioxygenase (> 2-fold) and the concentrations of l-kynurenine (> 2.5-fold). In contrast, no significant changes occured in two uninjured regions examined compared to controls, namely cervical spinal cord (C2) and the somatosensory cortex. Further studies of QUIN as a potential contributor to spinal cord injury are warranted.

本文言語English
ページ(範囲)314-316
ページ数3
ジャーナルBrain Research
632
1-2
DOI
出版ステータスPublished - 31-12-1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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