IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain

Qinglan Guo, Jiachun Su, Christi Lee McElheny, Nicole Stoesser, Yohei Doi, Minggui Wang

研究成果: Article査読

8 被引用数 (Scopus)

抄録

IncX plasmids are receiving much attention as vehicles of carbapenem and colistin resistance genes, such as blaNDM, blaKPC, and mcr-1. Among them, IncX2 subgroup plasmids remain rare. Here, we characterized IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain that were possibly generated as a consequence of recombination events between an R6K-like IncX2 plasmid and a pLN126_33-like IncX1 plasmid. Variable multidrug resistance mosaic regions were observed in these plasmids, indicating their potential to serve as flexible carriers of resistance genes. The diversity of IncX group plasmid backbones and accessory genes and the evolution of hybrid IncX plasmids pose a challenge in detecting and classifying them.

本文言語English
論文番号e00536-17
ジャーナルAntimicrobial agents and chemotherapy
61
7
DOI
出版ステータスPublished - 07-2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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