Indocyanine green angiography in Stargardt's disease

We performed indocyanine green angiography (ICG angiography) and fluorescein angiography in order to investigate the choroidal circulation in patients with Stargardt's flavimaculatus. Eight eyes of 4 patients in Groups 2-3 (Noble classification) were included in this study. In the area with 'dark choroid' in fluorescein angiography, ICG angiography revealed large choroidal vessels in all eyes, but some fluorescent choroidal vessels were dark around the atrophic macula and in the peripapillary area, which indicated a greater storage of lipofuscin within the retinal pigment epithelium in those areas. In the atrophic macula area, irregular hypofluorescence was observed in ICG angiography, which might be caused by filling defect and/or block. Many flecks revealed hyperfluorescence in fluorescein angiography and hypofluorescence in ICG angiography, suggesting that focal circulatory disturbances in the choriocapillaries exist beneath the flecks.