Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion

Toshiho Ohtsuki, Masayasu Matsumoto, Kazuo Kitagawa, Akihiko Taguchi, Yusuke Maeda, Ryuji Hata, Satoshi Ogawa, Hirokazu Ueda, Nobuo Handa, Takenobu Kamada

研究成果: Article

21 引用 (Scopus)

抜粋

Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.

元の言語English
ページ(範囲)279-284
ページ数6
ジャーナルBrain Research
614
発行部数1-2
DOI
出版物ステータスPublished - 18-06-1993
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • これを引用

    Ohtsuki, T., Matsumoto, M., Kitagawa, K., Taguchi, A., Maeda, Y., Hata, R., Ogawa, S., Ueda, H., Handa, N., & Kamada, T. (1993). Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion. Brain Research, 614(1-2), 279-284. https://doi.org/10.1016/0006-8993(93)91045-T