Induction of B-cell lymphoma in BALB/c nude mice with an ecotropic, B- tropic helper virus present in the murine AIDS virus stock

Lamin Tayar; Kyoko Higo; Yoshinao Kubo; Yun Wang; Ling Min Lu; Fengmin Zhang; Yasumasa Iwatani; Ling Wang; Takeshi Ono; Michiyuki Maeda; Hiroyuki Sakai; Akinori Ishimoto

doi:10.1128/jvi.73.2.1640-1644.1999

Induction of B-cell lymphoma in BALB/c nude mice with an ecotropic, B- tropic helper virus present in the murine AIDS virus stock

Lamin Tayar
, Kyoko Higo
, Yoshinao Kubo
, Yun Wang
, Ling Min Lu
, Fengmin Zhang
, Yasumasa Iwatani
, Ling Wang
, Takeshi Ono
, Michiyuki Maeda
, Hiroyuki Sakai
, Akinori Ishimoto

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

抄録

The pathogenicities of the murine AIDS (MAIDS) virus complex (LP-BM5) and ecotropic helper virus (BM5eco) isolated from the complex to BALB/c nude mice were studied to elucidate the possible role of replication-competent helper virus in inducing the monoclonal outgrowth of lymphoid cells. Neither LP-BM5 nor BM5eco was pathogenic in adult BALB/c nude mice. However, B-cell lymphoma developed with a very high frequency when either virus was inoculated into newborn BALB/c nude (nu/nu) mice. The cells from the B-cell lymphoma were easily transplanted into nude mice. These results suggested that ecotropic helper virus in the MAIDS virus complex plays an important role in inducing the monoclonal outgrowth of lymphoid cells under immunodeficient conditions caused by defective virus.

本文言語	英語
ページ（範囲）	1640-1644
ページ数	5
ジャーナル	Journal of Virology
巻	73
号	2
DOI	https://doi.org/10.1128/jvi.73.2.1640-1644.1999
出版ステータス	出版済み - 1999
外部発表	はい

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All Science Journal Classification (ASJC) codes

微生物学
免疫学
昆虫科学
ウイルス学

文献へのアクセス

10.1128/jvi.73.2.1640-1644.1999

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引用スタイル

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title = "Induction of B-cell lymphoma in BALB/c nude mice with an ecotropic, B- tropic helper virus present in the murine AIDS virus stock",

abstract = "The pathogenicities of the murine AIDS (MAIDS) virus complex (LP-BM5) and ecotropic helper virus (BM5eco) isolated from the complex to BALB/c nude mice were studied to elucidate the possible role of replication-competent helper virus in inducing the monoclonal outgrowth of lymphoid cells. Neither LP-BM5 nor BM5eco was pathogenic in adult BALB/c nude mice. However, B-cell lymphoma developed with a very high frequency when either virus was inoculated into newborn BALB/c nude (nu/nu) mice. The cells from the B-cell lymphoma were easily transplanted into nude mice. These results suggested that ecotropic helper virus in the MAIDS virus complex plays an important role in inducing the monoclonal outgrowth of lymphoid cells under immunodeficient conditions caused by defective virus.",

author = "Lamin Tayar and Kyoko Higo and Yoshinao Kubo and Yun Wang and Lu, \{Ling Min\} and Fengmin Zhang and Yasumasa Iwatani and Ling Wang and Takeshi Ono and Michiyuki Maeda and Hiroyuki Sakai and Akinori Ishimoto",

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AU - Tayar, Lamin

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AU - Kubo, Yoshinao

AU - Wang, Yun

AU - Lu, Ling Min

AU - Zhang, Fengmin

AU - Iwatani, Yasumasa

AU - Wang, Ling

AU - Ono, Takeshi

AU - Maeda, Michiyuki

AU - Sakai, Hiroyuki

AU - Ishimoto, Akinori

PY - 1999

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