Induction of Langerhans' cell mitosis in vivo after orchiectomy on mice

Y. I. Koyama, S. Nagao, K. Ohashi, H. Takahashi, T. Marunouchi

研究成果: Article

2 引用 (Scopus)

抄録

We recently reported that male mice have fewer Langerhans' cells (LCs) than females and that orchiectomy resulted in an increased LC density. In this study we demonstrate that orchiectomy induces a transient increase in the number of paired LCs (PLCs) before the increase in LC density occurs. The results of double staining for adenosine triphosphatase (ATPase) and 5-bromo-2'-deoxyuridine (BrdU) showed that all examined PLCs had incorporated the intraperitoneally injected BrdU, while only 0.7% of the unpaired LCs were BrdU-positive; that supported the notion of PLCs as being divided daughter LCs. Orchiectomy appears to induce a transient increase in mitotic activity of LCs resulting in the increased LC density.

元の言語English
ページ(範囲)505-508
ページ数4
ジャーナルActa Dermato-Venereologica
70
発行部数6
出版物ステータスPublished - 01-01-1990

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Orchiectomy
Langerhans Cells
Mitosis
Bromodeoxyuridine
Cell Count
Adenosine Triphosphatases
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

Koyama, Y. I. ; Nagao, S. ; Ohashi, K. ; Takahashi, H. ; Marunouchi, T. / Induction of Langerhans' cell mitosis in vivo after orchiectomy on mice. :: Acta Dermato-Venereologica. 1990 ; 巻 70, 番号 6. pp. 505-508.
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Koyama, YI, Nagao, S, Ohashi, K, Takahashi, H & Marunouchi, T 1990, 'Induction of Langerhans' cell mitosis in vivo after orchiectomy on mice', Acta Dermato-Venereologica, 巻. 70, 番号 6, pp. 505-508.

Induction of Langerhans' cell mitosis in vivo after orchiectomy on mice. / Koyama, Y. I.; Nagao, S.; Ohashi, K.; Takahashi, H.; Marunouchi, T.

:: Acta Dermato-Venereologica, 巻 70, 番号 6, 01.01.1990, p. 505-508.

研究成果: Article

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T1 - Induction of Langerhans' cell mitosis in vivo after orchiectomy on mice

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AU - Nagao, S.

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AB - We recently reported that male mice have fewer Langerhans' cells (LCs) than females and that orchiectomy resulted in an increased LC density. In this study we demonstrate that orchiectomy induces a transient increase in the number of paired LCs (PLCs) before the increase in LC density occurs. The results of double staining for adenosine triphosphatase (ATPase) and 5-bromo-2'-deoxyuridine (BrdU) showed that all examined PLCs had incorporated the intraperitoneally injected BrdU, while only 0.7% of the unpaired LCs were BrdU-positive; that supported the notion of PLCs as being divided daughter LCs. Orchiectomy appears to induce a transient increase in mitotic activity of LCs resulting in the increased LC density.

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