Induction of Langerhans' cell mitosis in vivo after orchiectomy on mice

Y. I. Koyama, S. Nagao, K. Ohashi, H. Takahashi, T. Marunouchi

研究成果: Article

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We recently reported that male mice have fewer Langerhans' cells (LCs) than females and that orchiectomy resulted in an increased LC density. In this study we demonstrate that orchiectomy induces a transient increase in the number of paired LCs (PLCs) before the increase in LC density occurs. The results of double staining for adenosine triphosphatase (ATPase) and 5-bromo-2'-deoxyuridine (BrdU) showed that all examined PLCs had incorporated the intraperitoneally injected BrdU, while only 0.7% of the unpaired LCs were BrdU-positive; that supported the notion of PLCs as being divided daughter LCs. Orchiectomy appears to induce a transient increase in mitotic activity of LCs resulting in the increased LC density.

元の言語English
ページ(範囲)505-508
ページ数4
ジャーナルActa Dermato-Venereologica
70
発行部数6
出版物ステータスPublished - 01-01-1990

All Science Journal Classification (ASJC) codes

  • Dermatology

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