Induction of trophinin in human endometrial surface epithelia by CGβ and IL-1β

Kazuhiro Sugihara, Maryam Kabir-Salmani, James Byrne, Don P. Wolf, Bruce Lessey, Mitsutoshi Iwashita, Daisuke Aoki, Jun Nakayama, Michiko N. Fukuda

研究成果: Article査読

37 被引用数 (Scopus)

抄録

During embryo implantation, trophinin mediates cell adhesion by homophilic binding at the apical surfaces of trophectoderm and endometrium. Trophinin is expressed on the human endometrial epithelia in rare occasions. We developed hCG-coated agarose beads that mimic the physical and physiological features of an implantation-stage human blastocyst. When hCG-coated beads were applied to human endometrial epithelial cells in the presence of IL-1β, endometrial cells acquired strong trophinin expression and the ability for apical cell adhesion with trophinin-expressing human trophoblastic cells. These results provide a mechanism for trophinin-mediated adhesion of human blastocyst to endometrium by a spatially and temporally restricted paracrine effect of hCG derived from the blastocyst.

本文言語English
ページ(範囲)197-202
ページ数6
ジャーナルFEBS Letters
582
2
DOI
出版ステータスPublished - 23-01-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

フィンガープリント

「Induction of trophinin in human endometrial surface epithelia by CGβ and IL-1β」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル