TY - JOUR
T1 - Infected aortic aneurysm caused by Helicobacter cinaedi
T2 - case series and systematic review of the literature
AU - Matsuo, Takahiro
AU - Mori, Nobuyoshi
AU - Mizuno, Atsushi
AU - Sakurai, Aki
AU - Kawai, Fujimi
AU - Starkey, Jay
AU - Ohkushi, Daisuke
AU - Abe, Kohei
AU - Yamasaki, Manabu
AU - Ito, Joji
AU - Yoshino, Kunihiko
AU - Mikami, Yumiko
AU - Uehara, Yuki
AU - Furukawa, Keiichi
N1 - Funding Information:
We wish to thank Dr. Kiyofumi Okusu, Department of Microbiology, Tokyo Medical University, for performing the 16S rRNA sequencing and Dr. Emiko Hayashihara, National Institute of Infectious Diseases, for the susceptibility testing identification.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12
Y1 - 2020/12
N2 - Background: Helicobacter cinaedi is rarely identified as a cause of infected aneurysms; however, the number of reported cases has been increasing over several decades, especially in Japan. We report three cases of aortic aneurysm infected by H. cinaedi that were successfully treated using meropenem plus surgical stent graft replacement or intravascular stenting. Furthermore, we performed a systematic review of the literature regarding aortic aneurysm infected by H. cinaedi. Case presentation: We present three rare cases of infected aneurysm caused by H. cinaedi in adults. Blood and tissue cultures and 16S rRNA gene sequencing were used for diagnosis. Two patients underwent urgent surgical stent graft replacement, and the other patient underwent intravascular stenting. All three cases were treated successfully with intravenous meropenem for 4 to 6 weeks. Conclusions: These cases suggest that although aneurysms infected by H. cinaedi are rare, clinicians should be aware of H. cinaedi as a potential causative pathogen, even in immunocompetent patients. Prolonged incubation periods for blood cultures are necessary for the accurate detection of H. cinaedi.
AB - Background: Helicobacter cinaedi is rarely identified as a cause of infected aneurysms; however, the number of reported cases has been increasing over several decades, especially in Japan. We report three cases of aortic aneurysm infected by H. cinaedi that were successfully treated using meropenem plus surgical stent graft replacement or intravascular stenting. Furthermore, we performed a systematic review of the literature regarding aortic aneurysm infected by H. cinaedi. Case presentation: We present three rare cases of infected aneurysm caused by H. cinaedi in adults. Blood and tissue cultures and 16S rRNA gene sequencing were used for diagnosis. Two patients underwent urgent surgical stent graft replacement, and the other patient underwent intravascular stenting. All three cases were treated successfully with intravenous meropenem for 4 to 6 weeks. Conclusions: These cases suggest that although aneurysms infected by H. cinaedi are rare, clinicians should be aware of H. cinaedi as a potential causative pathogen, even in immunocompetent patients. Prolonged incubation periods for blood cultures are necessary for the accurate detection of H. cinaedi.
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U2 - 10.1186/s12879-020-05582-7
DO - 10.1186/s12879-020-05582-7
M3 - Article
C2 - 33203370
AN - SCOPUS:85096098950
VL - 20
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
SN - 1471-2334
IS - 1
M1 - 854
ER -