Infection control in neutropenia induced by high-dose cytarabine chemotherapy

Masayuki Miyazaki, Kouji Senzaki, Hitoshi Kiyoi, Shigekatu Kohno, Yukihiro Noda, Toshitaka Nabeshima

研究成果: Article

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抜粋

A high-dose cytarabine (Cylocide; Ara-C: HDAC) chemotherapy has been successfully used as a postremission consolidation therapy for acute myeloid leukemia (AML). Although this chemotherapy has been estimated to cause severe myelosuppression, there has been no report about infection risk relating to HDAC chemotherapy. The purpose of this retrospective study is to evaluate the infection risk in AML patients treated with HDAC (n = 18) compared to those treated with standard-dose Ara-C (SDAC, n = 18). The mean duration of severe neutropenia (neutrophils < 500/microl) in HDAC group and SDAC was 14.8 days and 10.4 days, respectively, indicating a significant prolongation in the HDAC group (p < 0.05). The frequency of febrile neutropenia in the HDAC group tended to increase compared to that in the SDAC group (p = 0.093). The average days of usage of quinolone antimicrobial prophylaxis and aminoglycoside antibiotic injection in febrile neutropenia in the HDAC group were significantly longer than those of the SDAC group (quinolone; p < 0.01, aminoglycoside; p < 0.05). The frequency of Streptococcus infection isolated from pharyngeal mucus in the HDAC group was significantly higher than that in the SDAC group (100% versus 75%; p < 0.05). These results suggest that HDAC chemotherapy increased the infection risk compared to SDAC, and especially patients who received HDAC need a further prevention plan against gram-positive bacteria.

元の言語English
ページ(範囲)2011-2015
ページ数5
ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
31
発行部数12
出版物ステータスPublished - 11-2004
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Miyazaki, M., Senzaki, K., Kiyoi, H., Kohno, S., Noda, Y., & Nabeshima, T. (2004). Infection control in neutropenia induced by high-dose cytarabine chemotherapy. Gan to kagaku ryoho. Cancer & chemotherapy, 31(12), 2011-2015.