TY - JOUR
T1 - Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor
T2 - TNFα enhances GPR84 expression in adipocytes
AU - Nagasaki, Hiroshi
AU - Kondo, Takaaki
AU - Fuchigami, Masahiro
AU - Hashimoto, Hiroyuki
AU - Sugimura, Yoshihisa
AU - Ozaki, Nobuaki
AU - Arima, Hiroshi
AU - Ota, Akira
AU - Oiso, Yutaka
AU - Hamada, Yoji
PY - 2012/2/17
Y1 - 2012/2/17
N2 - In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.
AB - In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.
UR - http://www.scopus.com/inward/record.url?scp=84857051975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857051975&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2012.01.001
DO - 10.1016/j.febslet.2012.01.001
M3 - Article
C2 - 22245676
AN - SCOPUS:84857051975
VL - 586
SP - 368
EP - 372
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 4
ER -