@article{c8c2aaa0e42d4a6aa46322afa47a25c8,
title = "Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes",
abstract = "In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.",
keywords = "Adiponectin, Adipose tissue, GPR84, Medium-chain fatty acid, TNFα",
author = "Hiroshi Nagasaki and Takaaki Kondo and Masahiro Fuchigami and Hiroyuki Hashimoto and Yoshihisa Sugimura and Nobuaki Ozaki and Hiroshi Arima and Akira Ota and Yutaka Oiso and Yoji Hamada",
note = "Funding Information: This study was partially funded by grant-in-aid (No. 22500331) from the Ministry of Education, Science and Culture of Japan. The authors acknowledge Ms. Michiko Yamada, Nagoya University, for her excellent technical assistance. We also thank Dr. Larry Frye of BIOMEDCOM for the help in the preparation of this manuscript. There are no conflicts of interest regarding this study. ",
year = "2012",
month = feb,
day = "17",
doi = "10.1016/j.febslet.2012.01.001",
language = "English",
volume = "586",
pages = "368--372",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "4",
}