Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes

Hiroshi Nagasaki; Takaaki Kondo; Masahiro Fuchigami; Hiroyuki Hashimoto; Yoshihisa Sugimura; Nobuaki Ozaki; Hiroshi Arima; Akira Ota; Yutaka Oiso; Yoji Hamada

doi:10.1016/j.febslet.2012.01.001

Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes

Hiroshi Nagasaki
, Takaaki Kondo
, Masahiro Fuchigami
, Hiroyuki Hashimoto
, Yoshihisa Sugimura
, Nobuaki Ozaki
, Hiroshi Arima
, Akira Ota
, Yutaka Oiso
, Yoji Hamada

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

86 被引用数 (Scopus)

抄録

In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.

本文言語	英語
ページ（範囲）	368-372
ページ数	5
ジャーナル	FEBS Letters
巻	586
号	4
DOI	https://doi.org/10.1016/j.febslet.2012.01.001
出版ステータス	出版済み - 17-02-2012
外部発表	はい

All Science Journal Classification (ASJC) codes

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

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10.1016/j.febslet.2012.01.001

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「Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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title = "Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes",

abstract = "In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.",

keywords = "Adiponectin, Adipose tissue, GPR84, Medium-chain fatty acid, TNFα",

author = "Hiroshi Nagasaki and Takaaki Kondo and Masahiro Fuchigami and Hiroyuki Hashimoto and Yoshihisa Sugimura and Nobuaki Ozaki and Hiroshi Arima and Akira Ota and Yutaka Oiso and Yoji Hamada",

note = "Funding Information: This study was partially funded by grant-in-aid (No. 22500331) from the Ministry of Education, Science and Culture of Japan. The authors acknowledge Ms. Michiko Yamada, Nagoya University, for her excellent technical assistance. We also thank Dr. Larry Frye of BIOMEDCOM for the help in the preparation of this manuscript. There are no conflicts of interest regarding this study. ",

year = "2012",

month = feb,

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doi = "10.1016/j.febslet.2012.01.001",

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T1 - Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor

T2 - TNFα enhances GPR84 expression in adipocytes

AU - Nagasaki, Hiroshi

AU - Kondo, Takaaki

AU - Fuchigami, Masahiro

AU - Hashimoto, Hiroyuki

AU - Sugimura, Yoshihisa

AU - Ozaki, Nobuaki

AU - Arima, Hiroshi

AU - Ota, Akira

AU - Oiso, Yutaka

AU - Hamada, Yoji

N1 - Funding Information: This study was partially funded by grant-in-aid (No. 22500331) from the Ministry of Education, Science and Culture of Japan. The authors acknowledge Ms. Michiko Yamada, Nagoya University, for her excellent technical assistance. We also thank Dr. Larry Frye of BIOMEDCOM for the help in the preparation of this manuscript. There are no conflicts of interest regarding this study.

PY - 2012/2/17

Y1 - 2012/2/17

N2 - In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.

AB - In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.

KW - Adiponectin

KW - Adipose tissue

KW - GPR84

KW - Medium-chain fatty acid

KW - TNFα

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DO - 10.1016/j.febslet.2012.01.001

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