Inflammatory Mediators in Postoperative Aphakic and Pseudophakic Baboon Eyes

Kensaku Miyake, Hiroyuki Mibu, Masayuki Horiguchi, Eiichi Shirasawa

研究成果: Article査読

56 被引用数 (Scopus)

抄録

We measured prostaglandin E2 and leukotriene B4 in the aqueous humor of baboon eyes, 1 or 8 days after phacoemulsification, with or without posterior chamber lens implantation. We also evaluated the effects of steroid eye drops and cyclooxygenase inhibitor eye drops on the synthesis of these mediators of inflammation. Eyes that had undergone phacoemulsification showed significant elevation of prostaglandin E2 at both postoperative periods compared with normal, phakic control eyes. The level of prostaglandin E2 was significantly (P<.05) higher in eyes with posterior chamber lens implantation than in those without it, and was significantly (P<.05) higher on the eighth than on the first postoperative day. The amount of leukotriene B4 was below the detection limit, except in the few eyes in which complications developed. Cyclooxygenase inhibitor eye drops significantly reduced the amount of prostaglandin E2 on both postoperative days, while steroid eye drops had no such effect.

本文言語English
ページ(範囲)1764-1767
ページ数4
ジャーナルArchives of Ophthalmology
108
12
DOI
出版ステータスPublished - 12-1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • 眼科学

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