Influence of anesthesia on brain distribution of [11C]methamphetamine in monkeys in positron emission tomography (PET) study

Michinao Mizugaki, Naoto Nakagawa, Hitoshi Nakamura, Takanori Hishinuma, Yoshihisa Tomioka, Shunji Ishiwata, Tatsuo Ido, Ren Iwata, Yoshihito Funaki, Masatoshi Itoh, Masato Higuchi, Nobuyuki Okamura, Takehiko Fujiwara, Mitsutomo Sato, Katsuhiro Shindo, Sumiko Yoshida

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

We investigated the influence of anesthesia on the brain distribution of [11C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [11C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.

本文言語英語
ページ(範囲)173-175
ページ数3
ジャーナルBrain Research
911
2
DOI
出版ステータス出版済み - 24-08-2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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