Influence of R-CHOP therapy on immune system restoration in patients with b-cell lymphoma

Kaori Ito, Masataka Okamoto, Yoko Inaguma, Akinao Okamoto, Maiko Ando, Yosuke Ando, Masahiro Tsuge, Ayana Tomono, Yukiko Kakumae, Takahiro Hayashi, Shigeki Yamada, Nobuhiko Emi

研究成果: Article

5 引用 (Scopus)

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Objective: To assess the immunosuppressive effect of R-CHOP in patients with B-cell lymphoma at 2 years. Methods: Parameters of humoral and cell-mediated immunity were assessed in 89 patients with diffuse large B-cell lymphoma or follicular lymphoma before and after 6-8 cycles of R-CHOP-14 or R-CHOP-21 regimen. Results: Data on pre- and posttreatment serum IgG (sIgG) levels were available for all 89 patients, while the corresponding data on serum CD20+, CD3+, CD4+, and CD8+ lymphocyte counts were available in only 43. Median sIgG levels significantly decreased from 1,221 mg/dl (baseline) to 733 mg/dl (after chemotherapy) (p < 0.001). Although CD20+ and CD4+ cell counts decreased (p < 0.001), no significant effect of chemotherapy on CD3+ and CD8+ cell counts was observed. CD20+ cell counts were restored to baseline levels at the 12-month follow-up. sIgG levels and CD4+ cell counts were not completely restored at 24 months, indicating a sustained immunosuppressive effect of R-CHOP in these patients. The incidence of infections over the 2-year period was 16.3-23.6%. Conclusion: The immunosuppressive effect of R-CHOP in newly diagnosed cases of B-cell lymphoma tends to persist for >2 years, although sIgG levels were restored more quickly than CD4+ cell counts.

元の言語English
ページ(範囲)302-310
ページ数9
ジャーナルOncology (Switzerland)
91
発行部数6
DOI
出版物ステータスPublished - 01-11-2016

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Immune System
Lymphoma
Immunoglobulin G
CD4 Lymphocyte Count
Serum
Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Therapeutics
Immunosuppressive Agents
Cellular Immunity
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Ito, Kaori ; Okamoto, Masataka ; Inaguma, Yoko ; Okamoto, Akinao ; Ando, Maiko ; Ando, Yosuke ; Tsuge, Masahiro ; Tomono, Ayana ; Kakumae, Yukiko ; Hayashi, Takahiro ; Yamada, Shigeki ; Emi, Nobuhiko. / Influence of R-CHOP therapy on immune system restoration in patients with b-cell lymphoma. :: Oncology (Switzerland). 2016 ; 巻 91, 番号 6. pp. 302-310.
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abstract = "Objective: To assess the immunosuppressive effect of R-CHOP in patients with B-cell lymphoma at 2 years. Methods: Parameters of humoral and cell-mediated immunity were assessed in 89 patients with diffuse large B-cell lymphoma or follicular lymphoma before and after 6-8 cycles of R-CHOP-14 or R-CHOP-21 regimen. Results: Data on pre- and posttreatment serum IgG (sIgG) levels were available for all 89 patients, while the corresponding data on serum CD20+, CD3+, CD4+, and CD8+ lymphocyte counts were available in only 43. Median sIgG levels significantly decreased from 1,221 mg/dl (baseline) to 733 mg/dl (after chemotherapy) (p < 0.001). Although CD20+ and CD4+ cell counts decreased (p < 0.001), no significant effect of chemotherapy on CD3+ and CD8+ cell counts was observed. CD20+ cell counts were restored to baseline levels at the 12-month follow-up. sIgG levels and CD4+ cell counts were not completely restored at 24 months, indicating a sustained immunosuppressive effect of R-CHOP in these patients. The incidence of infections over the 2-year period was 16.3-23.6{\%}. Conclusion: The immunosuppressive effect of R-CHOP in newly diagnosed cases of B-cell lymphoma tends to persist for >2 years, although sIgG levels were restored more quickly than CD4+ cell counts.",
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Ito, K, Okamoto, M, Inaguma, Y, Okamoto, A, Ando, M, Ando, Y, Tsuge, M, Tomono, A, Kakumae, Y, Hayashi, T, Yamada, S & Emi, N 2016, 'Influence of R-CHOP therapy on immune system restoration in patients with b-cell lymphoma', Oncology (Switzerland), 巻. 91, 番号 6, pp. 302-310. https://doi.org/10.1159/000449251

Influence of R-CHOP therapy on immune system restoration in patients with b-cell lymphoma. / Ito, Kaori; Okamoto, Masataka; Inaguma, Yoko; Okamoto, Akinao; Ando, Maiko; Ando, Yosuke; Tsuge, Masahiro; Tomono, Ayana; Kakumae, Yukiko; Hayashi, Takahiro; Yamada, Shigeki; Emi, Nobuhiko.

:: Oncology (Switzerland), 巻 91, 番号 6, 01.11.2016, p. 302-310.

研究成果: Article

TY - JOUR

T1 - Influence of R-CHOP therapy on immune system restoration in patients with b-cell lymphoma

AU - Ito, Kaori

AU - Okamoto, Masataka

AU - Inaguma, Yoko

AU - Okamoto, Akinao

AU - Ando, Maiko

AU - Ando, Yosuke

AU - Tsuge, Masahiro

AU - Tomono, Ayana

AU - Kakumae, Yukiko

AU - Hayashi, Takahiro

AU - Yamada, Shigeki

AU - Emi, Nobuhiko

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Objective: To assess the immunosuppressive effect of R-CHOP in patients with B-cell lymphoma at 2 years. Methods: Parameters of humoral and cell-mediated immunity were assessed in 89 patients with diffuse large B-cell lymphoma or follicular lymphoma before and after 6-8 cycles of R-CHOP-14 or R-CHOP-21 regimen. Results: Data on pre- and posttreatment serum IgG (sIgG) levels were available for all 89 patients, while the corresponding data on serum CD20+, CD3+, CD4+, and CD8+ lymphocyte counts were available in only 43. Median sIgG levels significantly decreased from 1,221 mg/dl (baseline) to 733 mg/dl (after chemotherapy) (p < 0.001). Although CD20+ and CD4+ cell counts decreased (p < 0.001), no significant effect of chemotherapy on CD3+ and CD8+ cell counts was observed. CD20+ cell counts were restored to baseline levels at the 12-month follow-up. sIgG levels and CD4+ cell counts were not completely restored at 24 months, indicating a sustained immunosuppressive effect of R-CHOP in these patients. The incidence of infections over the 2-year period was 16.3-23.6%. Conclusion: The immunosuppressive effect of R-CHOP in newly diagnosed cases of B-cell lymphoma tends to persist for >2 years, although sIgG levels were restored more quickly than CD4+ cell counts.

AB - Objective: To assess the immunosuppressive effect of R-CHOP in patients with B-cell lymphoma at 2 years. Methods: Parameters of humoral and cell-mediated immunity were assessed in 89 patients with diffuse large B-cell lymphoma or follicular lymphoma before and after 6-8 cycles of R-CHOP-14 or R-CHOP-21 regimen. Results: Data on pre- and posttreatment serum IgG (sIgG) levels were available for all 89 patients, while the corresponding data on serum CD20+, CD3+, CD4+, and CD8+ lymphocyte counts were available in only 43. Median sIgG levels significantly decreased from 1,221 mg/dl (baseline) to 733 mg/dl (after chemotherapy) (p < 0.001). Although CD20+ and CD4+ cell counts decreased (p < 0.001), no significant effect of chemotherapy on CD3+ and CD8+ cell counts was observed. CD20+ cell counts were restored to baseline levels at the 12-month follow-up. sIgG levels and CD4+ cell counts were not completely restored at 24 months, indicating a sustained immunosuppressive effect of R-CHOP in these patients. The incidence of infections over the 2-year period was 16.3-23.6%. Conclusion: The immunosuppressive effect of R-CHOP in newly diagnosed cases of B-cell lymphoma tends to persist for >2 years, although sIgG levels were restored more quickly than CD4+ cell counts.

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