Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot

Mitsuo Miyazawa; Hirotoshi Utsunomiya; Ken Ichi Inada; Tomoki Yamada; Yoshiharu Okuno; Harunari Tanaka; Masae Tatematsu

doi:10.1248/bpb.29.172

Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot

Mitsuo Miyazawa
, Hirotoshi Utsunomiya
, Ken Ichi Inada
, Tomoki Yamada
, Yoshiharu Okuno
, Harunari Tanaka
, Masae Tatematsu

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

69 被引用数 (Scopus)

抄録

A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited ≥90% of the H. pylori motility at a concentration of 500 μg/ml and the IC₅₀ value was 50 μg/ml.

本文言語	英語
ページ（範囲）	172-173
ページ数	2
ジャーナル	Biological and Pharmaceutical Bulletin
巻	29
号	1
DOI	https://doi.org/10.1248/bpb.29.172
出版ステータス	出版済み - 01-2006
外部発表	はい

All Science Journal Classification (ASJC) codes

薬理学
薬科学

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10.1248/bpb.29.172

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title = "Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot",

abstract = "A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited ≥90\% of the H. pylori motility at a concentration of 500 μg/ml and the IC50 value was 50 μg/ml.",

keywords = "(+)-syringaresinol, Helicobacter pylori, Japanese apricot",

author = "Mitsuo Miyazawa and Hirotoshi Utsunomiya and Inada, \{Ken Ichi\} and Tomoki Yamada and Yoshiharu Okuno and Harunari Tanaka and Masae Tatematsu",

year = "2006",

month = jan,

doi = "10.1248/bpb.29.172",

language = "English",

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T1 - Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot

AU - Miyazawa, Mitsuo

AU - Utsunomiya, Hirotoshi

AU - Inada, Ken Ichi

AU - Yamada, Tomoki

AU - Okuno, Yoshiharu

AU - Tanaka, Harunari

AU - Tatematsu, Masae

PY - 2006/1

Y1 - 2006/1

N2 - A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited ≥90% of the H. pylori motility at a concentration of 500 μg/ml and the IC50 value was 50 μg/ml.

AB - A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited ≥90% of the H. pylori motility at a concentration of 500 μg/ml and the IC50 value was 50 μg/ml.

KW - (+)-syringaresinol

KW - Helicobacter pylori

KW - Japanese apricot

UR - https://www.scopus.com/pages/publications/29844441430

UR - https://www.scopus.com/pages/publications/29844441430#tab=citedBy

U2 - 10.1248/bpb.29.172

DO - 10.1248/bpb.29.172

M3 - Article

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AN - SCOPUS:29844441430

SN - 0918-6158

VL - 29

SP - 172

EP - 173

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 1

ER -

Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot

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