Inhibition of the Action of a Stimulatory GDP/GTP Exchange Protein for smg p21 hy Acidic Membrane Phospholipids

Shiro Kawamura, Kozo Kaibuchi, Motoki Hiroyoshi, Hiroyuki Fujioka, Takakazu Mizuno, Yoshimi Takai

研究成果: Article査読

5 被引用数 (Scopus)

抄録

A stimulatory GDP/GTP exchange protein for smg p21 (smg p21 GDS) stimulated the dissociation of GDP from smg p21B. This reaction was inhibited by acidic membrane phospholipids such as phosphatidylinositol, phosphatidylinositol‐4‐monophosphate, phosphatidylinositol‐4‐,5‐bisphosphate, phosphatidic acid, and phosphatidylserine but not by phosphatidykholine or phosphatidylethanolamine. These acidic phospholipids inhibited the smg p21 GDS action in a manner competitive with both smg p21 GDS and smg p21B. smg p21 GDS has other actions to inhibit the binding of smg p21B to membranes and to induce the dissociation of prebound smg p21B from the membranes. The acidic phospholipids also inhibited these two actions of smg p21 GDS. smgp21B has a polybasic region and an isoprenoid moiety in its C‐terminal region which are necessary for its membrane‐binding activity and its sensitivity to the smg p21 GDS actions. Therefore, it is possible that acidic membrane phospholipids interact with this polybasic region and thereby inhibit the smg p21 GDS actions.

本文言語English
ページ(範囲)758-761
ページ数4
ジャーナルJapanese Journal of Cancer Research
82
7
DOI
出版ステータスPublished - 07-1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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