Inhibition of the metallo-β-lactamase produced from Serratia marcescens by thiol compounds

Masafumi Goto; Tatsuya Takahashi; Fumiko Yamashita; Ako Koreeda; Hiromasa Mori; Michio Ohta; Yoshichika Arakawa

doi:10.1248/bpb.20.1136

Inhibition of the metallo-β-lactamase produced from Serratia marcescens by thiol compounds

Masafumi Goto
, Tatsuya Takahashi
, Fumiko Yamashita
, Ako Koreeda
, Hiromasa Mori
, Michio Ohta
, Yoshichika Arakawa

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

70 被引用数 (Scopus)

抄録

Low molecular weight thiol compounds have been found to be strong inhibitors of metallo-β-lactamase (IMP-1) produced by Serratia marcescens TN9106, which was expressed by Echerichia coli JM109 cells. Mercaptoacetic acid and 2-mercaptopropionic acid strongly and competitively inhibited IMP-1 with K(i) of 0.23 and 0.19 μM, respectively. 2-Mercaptoethanol reversibly inhibited IMP-1 but did not show simple competitive inhibition.

本文言語	英語
ページ（範囲）	1136-1140
ページ数	5
ジャーナル	Biological and Pharmaceutical Bulletin
巻	20
号	11
DOI	https://doi.org/10.1248/bpb.20.1136
出版ステータス	出版済み - 1997
外部発表	はい

All Science Journal Classification (ASJC) codes

薬理学
薬科学

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10.1248/bpb.20.1136

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title = "Inhibition of the metallo-β-lactamase produced from Serratia marcescens by thiol compounds",

abstract = "Low molecular weight thiol compounds have been found to be strong inhibitors of metallo-β-lactamase (IMP-1) produced by Serratia marcescens TN9106, which was expressed by Echerichia coli JM109 cells. Mercaptoacetic acid and 2-mercaptopropionic acid strongly and competitively inhibited IMP-1 with K(i) of 0.23 and 0.19 μM, respectively. 2-Mercaptoethanol reversibly inhibited IMP-1 but did not show simple competitive inhibition.",

author = "Masafumi Goto and Tatsuya Takahashi and Fumiko Yamashita and Ako Koreeda and Hiromasa Mori and Michio Ohta and Yoshichika Arakawa",

year = "1997",

doi = "10.1248/bpb.20.1136",

language = "English",

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journal = "Biological and Pharmaceutical Bulletin",

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T1 - Inhibition of the metallo-β-lactamase produced from Serratia marcescens by thiol compounds

AU - Goto, Masafumi

AU - Takahashi, Tatsuya

AU - Yamashita, Fumiko

AU - Koreeda, Ako

AU - Mori, Hiromasa

AU - Ohta, Michio

AU - Arakawa, Yoshichika

PY - 1997

Y1 - 1997

N2 - Low molecular weight thiol compounds have been found to be strong inhibitors of metallo-β-lactamase (IMP-1) produced by Serratia marcescens TN9106, which was expressed by Echerichia coli JM109 cells. Mercaptoacetic acid and 2-mercaptopropionic acid strongly and competitively inhibited IMP-1 with K(i) of 0.23 and 0.19 μM, respectively. 2-Mercaptoethanol reversibly inhibited IMP-1 but did not show simple competitive inhibition.

AB - Low molecular weight thiol compounds have been found to be strong inhibitors of metallo-β-lactamase (IMP-1) produced by Serratia marcescens TN9106, which was expressed by Echerichia coli JM109 cells. Mercaptoacetic acid and 2-mercaptopropionic acid strongly and competitively inhibited IMP-1 with K(i) of 0.23 and 0.19 μM, respectively. 2-Mercaptoethanol reversibly inhibited IMP-1 but did not show simple competitive inhibition.

UR - https://www.scopus.com/pages/publications/0031391773

UR - https://www.scopus.com/pages/publications/0031391773#tab=citedBy

U2 - 10.1248/bpb.20.1136

DO - 10.1248/bpb.20.1136

M3 - Article

C2 - 9401719

AN - SCOPUS:0031391773

SN - 0918-6158

VL - 20

SP - 1136

EP - 1140

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 11

ER -

Inhibition of the metallo-β-lactamase produced from Serratia marcescens by thiol compounds

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