Inhibitory action of adenosine 3′,5′-monophosphate on phosphatidylinositol turnover: Difference in tissue response

Kozo Kaibuchi, Yoshimi Takai, Yasuhiro Ogawa, Shuji Kimura, Yasutomi Nishizuka, Toshikazu Nakamura, Akito Tomomura, Akira Ichihara

研究成果: ジャーナルへの寄稿学術論文査読

84 被引用数 (Scopus)

抄録

There appear to be considerable differences among tissues in the inhibitory action of adenosine 3′,5′-monophosphate (cyclic AMP) on phosphatidylinositol (PI) turnover induced by various extracellular signals. The present studies were on human peripheral lymphocytes and rat hepatocytes. In the lymphocyte system, cells are activated by phytohemagglutinin that induces PI turnover, and this PI turnover and cellular activation are profoundly blocked by dibutyryl cyclic AMP as well as by prostaglandin E1 which markedly increases cyclic AMP. In contrast, in the hepatocyte system, glycogenolysis is enhanced by α-agonists that induce PI turnover as well as by β-agonists and glucagon that increase cyclic AMP. In these cells the two classes of receptors appear to function independently, and PI turnover is not inhibited by cyclic AMP.

本文言語英語
ページ(範囲)105-112
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
104
1
DOI
出版ステータス出版済み - 15-01-1982
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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