Inhibitory action of guanosine 3′,5′-monophosphate on thrombin-induced phosphatidylinositol turnover and protein phosphorylation in human platelets

Yoshimi Takai, Kozo Kaibuchi, Tsukasa Matsubara, Yasutomi Nishizuka

研究成果: Article査読

99 被引用数 (Scopus)

抄録

Human platelets activated by thrombin rapidly produce diglyceride from phosphatidylinositol (PI). Concomitantly, a protein having a molecular weight of about 40,000 is heavily phosphorylated and serotonin is released. These reactions are inhibited in parallel manners by sodium nitroprusside which elevates cyclic GMP. 8-Bromocyclic GMP also inhibits the reactions. Instead, both agents stimulate the phosphorylation of a distinct protein having a molecular weight of about 50,000. Since stimulants of platelets such as thrombin normally increase cyclic GMP, the results imply that this cyclic nucleotide may be involved in a circuit leading to the feedback inhibition of PI hydrolysis presumably through protein phosphorylation.

本文言語English
ページ(範囲)61-67
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
101
1
DOI
出版ステータスPublished - 16-07-1981
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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