Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.

T. Yamaguchi, S. Izuta, M. Suzuki, S. Yoshida, A. Matsukage, M. Saneyoshi

研究成果: Article査読

抄録

Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

本文言語English
ページ(範囲)191-192
ページ数2
ジャーナルNucleic acids symposium series
27
出版ステータスPublished - 1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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