Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.

T. Yamaguchi; S. Izuta; M. Suzuki; S. Yoshida; A. Matsukage; M. Saneyoshi

Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.

T. Yamaguchi, S. Izuta, M. Suzuki, S. Yoshida, A. Matsukage, M. Saneyoshi

研究成果: Article › 査読

抄録

Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

本文言語	English
ページ（範囲）	191-192
ページ数	2
ジャーナル	Nucleic acids symposium series
号	27
出版ステータス	Published - 1992
外部発表	はい

All Science Journal Classification (ASJC) codes

Medicine(all)

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引用スタイル

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AU - Yamaguchi, T.

AU - Izuta, S.

AU - Suzuki, M.

AU - Yoshida, S.

AU - Matsukage, A.

AU - Saneyoshi, M.

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AB - Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

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