Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.

T. Yamaguchi; S. Izuta; M. Suzuki; S. Yoshida; A. Matsukage; M. Saneyoshi

Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.

T. Yamaguchi
, S. Izuta
, M. Suzuki
, S. Yoshida
, A. Matsukage
, M. Saneyoshi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

抄録

Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

本文言語	英語
ページ（範囲）	191-192
ページ数	2
ジャーナル	Nucleic acids symposium series
号	27
出版ステータス	出版済み - 1992
外部発表	はい

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All Science Journal Classification (ASJC) codes

医学一般

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引用スタイル

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abstract = "Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.",

author = "T. Yamaguchi and S. Izuta and M. Suzuki and S. Yoshida and A. Matsukage and M. Saneyoshi",

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T1 - Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.

AU - Yamaguchi, T.

AU - Izuta, S.

AU - Suzuki, M.

AU - Yoshida, S.

AU - Matsukage, A.

AU - Saneyoshi, M.

PY - 1992

Y1 - 1992

N2 - Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

AB - Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

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EP - 192

JO - Nucleic acids symposium series

JF - Nucleic acids symposium series

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