抄録
Alpha-synuclein (α-syn) and tau polymerize into amyloid fibrils and form intraneuronal filamentous inclusions characteristic of neurodegenerative diseases. We demonstrate that α-syn induces fibrillization of tau and that coincubation of tau and α-syn synergistically promotes fibrilization of both proteins. The in vivo relevance of these findings is grounded in the co-occurrence of α-syn and tau filamentous amyloid inclusions in humans, in single transgenic mice that express A53T human α-syn in neurons, and in oligodendrocytes of bigenic mice that express wild-type human α-syn plus P301L mutant tau. This suggests that interactions between α-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases.
本文言語 | 英語 |
---|---|
ページ(範囲) | 636-640 |
ページ数 | 5 |
ジャーナル | Science |
巻 | 300 |
号 | 5619 |
DOI | |
出版ステータス | 出版済み - 25-04-2003 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 一般