Integrin activation and matrix binding mediate cellular responses to mechanical stretch

Akira Katsumi, Tomoki Naoe, Tadashi Matsushita, Kozo Kaibuchi, Martin Alexander Schwartz

研究成果: Article査読

180 被引用数 (Scopus)

抄録

Mechanical tension is a critical determinant of cell growth, differentiation, apoptosis, migration, and development. Integrins have been implicated in sensing force but little is known about how forces are transduced to biochemical signals. We now show that mechanical strain stimulates conformational activation of integrin αvβ3 in NIH3T3 cells. Integrin activation is mediated by phosphoinositol 3-kinase and is followed by an increase in integrin binding to extracellular matrix proteins. Mechanical stretch stimulation of JNK was dependent on new integrin binding to extracellular matrix. These data define a molecular mechanism for the role of integrins in mechanotransduction.

本文言語English
ページ(範囲)16546-16549
ページ数4
ジャーナルJournal of Biological Chemistry
280
17
DOI
出版ステータスPublished - 29-04-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Integrin activation and matrix binding mediate cellular responses to mechanical stretch」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル