Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

Teru Kanda; Naoki Horikoshi; Takayuki Murata; Daisuke Kawashima; Atsuko Sugimoto; Yohei Narita; Hitoshi Kurumizaka; Tatsuya Tsurumi

doi:10.1074/jbc.M113.491167

Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

Teru Kanda
, Naoki Horikoshi
, Takayuki Murata
, Daisuke Kawashima
, Atsuko Sugimoto
, Yohei Narita
, Hitoshi Kurumizaka
, Tatsuya Tsurumi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

21 被引用数 (Scopus)

抄録

Background: Epstein-Barr virus episomes piggyback onto cellular chromosomes in latently infected cells. Results: EBNA1 was functionally sound even when arginines within its chromosome binding domains were replaced with lysines. Conclusion: The basic nature of the domains is critically important for the chromosome binding. Significance: Learning how EBNA1 attaches to chromosomes is crucial for understanding the mechanism of stable maintenance of viral episomes.

本文言語	英語
ページ（範囲）	24189-24199
ページ数	11
ジャーナル	Journal of Biological Chemistry
巻	288
号	33
DOI	https://doi.org/10.1074/jbc.M113.491167
出版ステータス	出版済み - 16-08-2013
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
分子生物学
細胞生物学

文献へのアクセス

10.1074/jbc.M113.491167

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引用スタイル

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AU - Kanda, Teru

AU - Horikoshi, Naoki

AU - Murata, Takayuki

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AU - Sugimoto, Atsuko

AU - Narita, Yohei

AU - Kurumizaka, Hitoshi

AU - Tsurumi, Tatsuya

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