Interaction between enkephalinergic and dopaminergic systems in stressful situations

Akira Katoh, Toshitaka Nabeshima, Tsutomu Kameyama

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Mice exhibit a marked suppression of mobility when they are placed in the same cage in which they had previously received an electric shock. This suppression of motility is believed to be a stress-induced response [D-Ala2,Met5]enkephalinamide (DAMEA, 40 and 80 nmol i.c.v.), a derivative resistant to [Met5]enkephalin-degrading enzyme activity, significantly attenuated the conditioned suppression of motility. The attenuation of conditioned suppression of motility induced by DAMEA was antagonized not only by naloxone (0.1 mg/kg s.c.), but also by 6-hydroxydopamine (6-OHDA, 100 μg/mouse, i.c.v.)-induced lessions of dopaminergic (DAergic) neurons. Pimozide (100 μg/kg i.p.) and a low dose of apomorphine (50 μg/kg s.c.) also inhibited the effect of DAMEA. In addition, DAMEA reversed the decrease in DA turnover in the striatum in the conditioned suppression group. These results suggest that the attenuation of conditioned suppression of motility induced by activation of the [Met5]enkephalinergic system may be related to the striatal DAergic system.

本文言語English
ページ(範囲)95-99
ページ数5
ジャーナルEuropean Journal of Pharmacology
193
1
DOI
出版ステータスPublished - 25-01-1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学

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