Interaction of Necl-4/CADM4 with ErbB3 and integrin α6β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly

Hirokazu Sugiyama, Kiyohito Mizutani, Souichi Kurita, Naomasa Okimoto, Yohei Shimono, Yoshimi Takai

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Nectin-like molecule 4 (Necl-4)/CADM4, a transmembrane cell-cell adhesion molecule with three Ig-like domains, was shown to serve as a tumor suppressor, but its mode of action has not been elucidated. In this study, we showed that Necl-4 interacted in cis with ErbB3 through their extracellular regions, recruited PTPN13 and inhibited the heregulin-induced activation of the ErbB2/ErbB3 signaling. In addition, we extended our previous finding that Necl-4 interacts in cis with integrin α6β4 through their extracellular regions and found that Necl-4 inhibited the phorbol ester-induced disassembly of hemidesmosomes. These results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly.

本文言語English
ページ(範囲)519-528
ページ数10
ジャーナルGenes to Cells
18
6
DOI
出版ステータスPublished - 06-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 細胞生物学

フィンガープリント

「Interaction of Necl-4/CADM4 with ErbB3 and integrin α<sub>6</sub>β<sub>4</sub> and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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