@article{1095301cc1e445aa97e8d2c409ebad1f,
title = "Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae. Conservation of GDI membrane dissociation activity",
abstract = "Rab GDP dissociation inhibitor (Rab GDI), will induce the dissociation of GDP-bound rab3A from synaptic membranes and will inhibit GDP dissociation from Sec4, a member of the Rab subgroup of the Ras GTPase superfamily which is required for exocytosis in Saccharomyces cerevisiae. We report that Rab GDI releases GDP-bound Sec4 from yeast membranes. dGDI, a Drosophila homologue can similarly inhibit GDP dissociation from Sec4 and release GDP-bound Sec4 from yeast membranes. An activity partially purified from yeast cytosol dissociates GDP-bound Sec4 from yeast membranes, suggesting that yeast also possess a GDI protein that functions to recycle Sec4 from its target membrane.",
author = "Garrett, {Michelle D.} and Kabcenell, {Alisa K.} and Zahner, {Joseph E.} and Kozo Kaibuchi and Takuya Sasaki and Yoshimi Takai and Cheney, {Clarissa M.} and Novick, {Peter J.}",
note = "Funding Information: Acknowledgements:W e thank P.J. Brennwaldf or helpfuld iscussions and H. Tan for assistancew ith photographyM. .D.G. is a Lucille P. Markey VisitingF ellow and is supportedb y a grantf rom the Lucille P. Markey CharitableT rust. This work was supportedb y Grant MCB920569f7r om theN ationalS cienceF oundation( to C.M.C.) and Grants GM35370 and CA46128 from the National Institutes of Health (to P.J.N.).",
year = "1993",
month = oct,
day = "4",
doi = "10.1016/0014-5793(93)80343-S",
language = "English",
volume = "331",
pages = "233--238",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "3",
}