Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes

Patrik Nyberg, Takao Sakai, Kyu Hong Cho, Michael G. Caparon, Reinhard Fässler, Lars Björck

研究成果: ジャーナルへの寄稿学術論文査読

42 被引用数 (Scopus)

抄録

Fibronectin-binding surface proteins are found in many bacterial species. Most strains of Streptococcus pyogenes, a major human pathogen, express the fibronectin-binding protein F1, which promotes bacterial adherence to and entry into human cells. In this study, the role of fibronectin in S. pyogenes virulence was investigated by introducing the protein F1 gene in an S. pyogenes strain lacking this gene. Furthermore, transgenic mice lacking plasma fibronectin were used to examine the relative contribution of plasma and cellular fibronectin to S. pyogenes virulence. Unexpectedly, protein F1-expressing bacteria were less virulent to normal mice, and virulence was partly restored when these bacteria were used to infect mice lacking plasma fibronectin. Dissemination to the spleen of infected mice was less efficient for fibronectin-binding bacteria. These bacteria also disseminated more efficiently in mice lacking plasma fibronectin, demonstrating that plasma fibronectin bound to the bacterial surface downregulates S. pyogenes virulence by limiting bacterial spread. From an evolutionary point of view, these results suggest that reducing virulence by binding fibronectin adds selective advantages to the bacterium.

本文言語英語
ページ(範囲)2166-2174
ページ数9
ジャーナルEMBO Journal
23
10
DOI
出版ステータス出版済み - 19-05-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般
  • 分子生物学
  • 生化学、遺伝学、分子生物学一般
  • 免疫学および微生物学一般

フィンガープリント

「Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル