抄録
The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.
本文言語 | English |
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ページ(範囲) | 85-92 |
ページ数 | 8 |
ジャーナル | Cancer Letters |
巻 | 225 |
号 | 1 |
DOI | |
出版ステータス | Published - 08-07-2005 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research