Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Amaylia Oehadian; Naoki Koide; Mya Mu Mya; Ferdaus Hassan; Shamima Islam; Tomoaki Yoshida; Takashi Yokochi

doi:10.1016/j.canlet.2004.11.054

Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Amaylia Oehadian, Naoki Koide, Mya Mu Mya, Ferdaus Hassan, Shamima Islam, Tomoaki Yoshida, Takashi Yokochi

研究成果: Article › 査読

16 被引用数 (Scopus)

抄録

The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.

本文言語	English
ページ（範囲）	85-92
ページ数	8
ジャーナル	Cancer Letters
巻	225
号	1
DOI	https://doi.org/10.1016/j.canlet.2004.11.054
出版ステータス	Published - 08-07-2005
外部発表	はい

All Science Journal Classification (ASJC) codes

腫瘍学
癌研究

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10.1016/j.canlet.2004.11.054

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title = "Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)",

abstract = "The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.",

author = "Amaylia Oehadian and Naoki Koide and Mya, {Mya Mu} and Ferdaus Hassan and Shamima Islam and Tomoaki Yoshida and Takashi Yokochi",

note = "Funding Information: This work was partially supported by a Grant for Foreign Researcher from Aichi Medical University School of Medicine.",

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Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). / Oehadian, Amaylia; Koide, Naoki; Mya, Mya Mu; Hassan, Ferdaus; Islam, Shamima; Yoshida, Tomoaki; Yokochi, Takashi.

In: Cancer Letters, Vol. 225, No. 1, 08.07.2005, p. 85-92.

研究成果: Article › 査読

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AU - Koide, Naoki

AU - Mya, Mya Mu

AU - Hassan, Ferdaus

AU - Islam, Shamima

AU - Yoshida, Tomoaki

AU - Yokochi, Takashi

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