Intracellular and extracellular control of activin function by novel regulatory molecules

Kunihiro Tsuchida, Takashi Matsuzaki, Norio Yamakawa, Zhong Hui Liu, Hiromu Sugino

研究成果: Article

42 引用 (Scopus)

抄録

Activin signal transduction is regulated through multiple mechanisms. We have identified novel regulatory proteins that control activin functions either intracellularly or extracellularly. As intracellular molecules, PSD-95/Dlg/ZO-1 (PDZ) proteins that specifically associate with activin type II receptors (ActRIIs) were identified. We have named the molecules as activin receptor-interacting proteins (ARIPs). ARIP1 has two WW domains and five PDZ domains, associates not only with ActRIIs but also with Smads, and controls activin functions intracellularly in neuronal cells. Another ARIP we have found has only one PDZ domain, and is likely to be involved in intracellular trafficking and sorting of activin receptor complexes in the cell. As an extracellular regulatory protein, we have identified a novel follistatin-like protein, named follistatin-related gene (FLRG). Like follistatins, FLRG binds activins and bone morphogenetic proteins (BMPs) and controls their functions extracellularly. The mode of association of follistatin and FLRG with activins and their expression patterns are different, suggesting the distinct functions of follistatin and FLRG in vivo.

元の言語English
ページ(範囲)25-31
ページ数7
ジャーナルMolecular and Cellular Endocrinology
180
発行部数1-2
DOI
出版物ステータスPublished - 30-07-2001

Fingerprint

Follistatin
Activins
Activin Receptors
Molecules
Receptor-Interacting Protein Serine-Threonine Kinases
Genes
Follistatin-Related Proteins
Type II Activin Receptors
Proteins
Bone Morphogenetic Proteins
Signal transduction
Sorting
Signal Transduction
Association reactions

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

これを引用

Tsuchida, Kunihiro ; Matsuzaki, Takashi ; Yamakawa, Norio ; Liu, Zhong Hui ; Sugino, Hiromu. / Intracellular and extracellular control of activin function by novel regulatory molecules. :: Molecular and Cellular Endocrinology. 2001 ; 巻 180, 番号 1-2. pp. 25-31.
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Intracellular and extracellular control of activin function by novel regulatory molecules. / Tsuchida, Kunihiro; Matsuzaki, Takashi; Yamakawa, Norio; Liu, Zhong Hui; Sugino, Hiromu.

:: Molecular and Cellular Endocrinology, 巻 180, 番号 1-2, 30.07.2001, p. 25-31.

研究成果: Article

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