Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals

Shinji Kawaguchi; Yusuke Soma; Kazuaki Nakajima; Hideaki Kanazawa; Shugo Tohyama; Ryota Tabei; Akinori Hirano; Noriko Handa; Yoshitake Yamada; Shigeo Okuda; Shuji Hishikawa; Takumi Teratani; Satoshi Kunita; Yoshikazu Kishino; Marina Okada; Sho Tanosaki; Shota Someya; Yuika Morita; Hidenori Tani; Yujiro Kawai; Masataka Yamazaki; Akira Ito; Rei Shibata; Toyoaki Murohara; Yasuhiko Tabata; Eiji Kobayashi; Hideyuki Shimizu; Keiichi Fukuda; Jun Fujita

doi:10.1016/j.jacbts.2020.11.017

Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals

Shinji Kawaguchi
, Yusuke Soma
, Kazuaki Nakajima
, Hideaki Kanazawa
, Shugo Tohyama
, Ryota Tabei
, Akinori Hirano
, Noriko Handa
, Yoshitake Yamada
, Shigeo Okuda
, Shuji Hishikawa
, Takumi Teratani
, Satoshi Kunita
, Yoshikazu Kishino
, Marina Okada
, Sho Tanosaki
, Shota Someya
, Yuika Morita
, Hidenori Tani
, Yujiro Kawai

Masataka Yamazaki, Akira Ito, Rei Shibata, Toyoaki Murohara, Yasuhiko Tabata, Eiji Kobayashi, Hideyuki Shimizu, Keiichi Fukuda, Jun Fujita

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

91 被引用数 (Scopus)

抄録

The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study.

本文言語	英語
ページ（範囲）	239-254
ページ数	16
ジャーナル	JACC: Basic to Translational Science
巻	6
号	3
DOI	https://doi.org/10.1016/j.jacbts.2020.11.017
出版ステータス	出版済み - 03-2021
外部発表	はい

All Science Journal Classification (ASJC) codes

循環器および心血管医学

文献へのアクセス

10.1016/j.jacbts.2020.11.017

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引用スタイル

Kawaguchi, S., Soma, Y., Nakajima, K., Kanazawa, H., Tohyama, S., Tabei, R., Hirano, A., Handa, N., Yamada, Y., Okuda, S., Hishikawa, S., Teratani, T., Kunita, S., Kishino, Y., Okada, M., Tanosaki, S., Someya, S., Morita, Y., Tani, H., ... Fujita, J. (2021). Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals. JACC: Basic to Translational Science, 6(3), 239-254. https://doi.org/10.1016/j.jacbts.2020.11.017

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abstract = "The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study.",

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Kawaguchi, S, Soma, Y, Nakajima, K, Kanazawa, H, Tohyama, S, Tabei, R, Hirano, A, Handa, N, Yamada, Y, Okuda, S, Hishikawa, S, Teratani, T, Kunita, S, Kishino, Y, Okada, M, Tanosaki, S, Someya, S, Morita, Y, Tani, H, Kawai, Y, Yamazaki, M, Ito, A, Shibata, R, Murohara, T, Tabata, Y, Kobayashi, E, Shimizu, H, Fukuda, K & Fujita, J 2021, 'Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals', JACC: Basic to Translational Science, vol. 6, no. 3, pp. 239-254. https://doi.org/10.1016/j.jacbts.2020.11.017

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AU - Tohyama, Shugo

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AU - Hishikawa, Shuji

AU - Teratani, Takumi

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AU - Kishino, Yoshikazu

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AU - Tanosaki, Sho

AU - Someya, Shota

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AU - Tani, Hidenori

AU - Kawai, Yujiro

AU - Yamazaki, Masataka

AU - Ito, Akira

AU - Shibata, Rei

AU - Murohara, Toyoaki

AU - Tabata, Yasuhiko

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AU - Fukuda, Keiichi

AU - Fujita, Jun

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KW - cardiac spheroids

KW - cardiomyocyte

KW - cell transplantation

KW - heart failure

KW - human iPS cells

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