Intrinsic nucleoside diphosphate kinase-like activity as a novel function of 14-3-3 proteins

Mihiro Yano, Sachie Mori, Yasuharu Niwa, Masahiro Inoue, Hiroshi Kido

研究成果: ジャーナルへの寄稿学術論文査読

13 被引用数 (Scopus)

抄録

14-3-3 proteins play a role in many cellular functions as molecular chaperone and adapter proteins: they bind to and modulate several proteins involved in cell proliferation and differentiation, and also function ATP-dependently in targeting of precursors to mitochondria. We show here that 14-3-3 purified from a human lymphoblastoma and also its recombinant τ isoform exhibited intrinsic nucleoside diphosphate (NDP) kinase-like activity. 14-3-3 proteins preferentially catalyzed the transfer of the γ-phosphate group from ATP, dATP or dGTP to all nucleoside diphosphates and this transfer involved acid-labile phosphoenzyme intermediates. They also simultaneously catalyzed the reverse reaction of ATP hydrolysis. These properties of 14-3-3 are similar to those of NDP kinase, but not to those of adenylate kinase.

本文言語英語
ページ(範囲)244-248
ページ数5
ジャーナルFEBS Letters
419
2-3
DOI
出版ステータス出版済み - 15-12-1997

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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