Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms

T. Yoshikawa, M. Ihira, K. Suzuki, S. Suga, T. Matsubara, S. Furukawa, Y. Asano

研究成果: Article査読

46 被引用数 (Scopus)

抄録

Methods - A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction. Results - Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B. Conclusion - These data suggest that HHV-7 may invade the CNS.

本文言語English
ページ(範囲)170-171
ページ数2
ジャーナルArchives of Disease in Childhood
83
2
DOI
出版ステータスPublished - 2000

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康

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