TY - JOUR
T1 - Inverse association between diabetes and aortic dilatation in patients with advanced coronary artery disease
AU - Tanaka, Akihito
AU - Ishii, Hideki
AU - Oshima, Hideki
AU - Narita, Yuji
AU - Kodama, Akio
AU - Suzuki, Susumu
AU - Komori, Kimihiro
AU - Usui, Akihiko
AU - Murohara, Toyoaki
N1 - Funding Information:
Dr. Ishii has received lecture fees from Astellas and Otsuka. Dr. Murohara has received lecture fees from Bayer, Daiichi Sankyo, Dainippon Sumitomo, Kowa, MSD, Mitsubishi Tanabe, Nippon Boehringer Ingelheim, Novartis, Pfizer Japan, Sanofi-Aventis, and Takeda. Dr. Murohara has received unrestricted research grant for Department of Cardiology, Nagoya University Graduate School of Medicine, from Astellas (Tokyo, Japan), Daiichi Sankyo (Tokyo, Japan), Dainippon Sumitomo (Tokyo, Japan), Kowa (Nagoya, Japan), MSD (Tokyo, Japan), Mitsubishi Tanabe (Osaka, Japan), Nippon Boehringer Ingelheim (Tokyo, Japan), Novartis (Tokyo, Japan), Otsuka (Tokyo, Japan), Pfizer Japan (Tokyo, Japan), Sanofi-Aventis (Tokyo, Japan), Takeda (Tokyo, Japan), and Teijin (Tokyo, Japan).
Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Background: A negative association between diabetes and abdominal aortic aneurysm has recently been reported. The purpose of this study was to assess the relationship between diabetes and aortic diameter, including non-aneurysmal aortic diameter, in patients with advanced coronary artery disease. Methods: We identified 351 consecutive patients who had undergone coronary artery bypass graft surgery. The patients were divided into two groups: those with diabetes mellitus (DM) (DM+ group; n=180), and those without DM (DM- group; n=171). Infrarenal and ascending aortic diameters were measured by preoperative computed tomography and corrected for body surface area. Results: Infrarenal and ascending aortic diameters were significantly shorter in the DM+ group than in the DM- group (21.3±5.0mm vs. 24.7±9.8mm, p<0.001 and 36.0±4.4mm vs. 37.8±5.5mm, p=0.001, respectively). The rates of infrarenal aortic diameter ≥30mm and ascending aortic diameter ≥40mm were significantly lower in the DM+ group than in the DM- group (3.5% vs. 13.3%, p=0.003 and 14.2% vs. 24.1%, p=0.025, respectively). Multivariate models demonstrated diabetes to be an independent predictor of both infrarenal and ascending aortic diameters even after correction for body surface area. Conclusion: Our findings indicated an inverse association between diabetes and aortic dilatation of both the infrarenal and ascending aorta in patients with advanced coronary artery disease.
AB - Background: A negative association between diabetes and abdominal aortic aneurysm has recently been reported. The purpose of this study was to assess the relationship between diabetes and aortic diameter, including non-aneurysmal aortic diameter, in patients with advanced coronary artery disease. Methods: We identified 351 consecutive patients who had undergone coronary artery bypass graft surgery. The patients were divided into two groups: those with diabetes mellitus (DM) (DM+ group; n=180), and those without DM (DM- group; n=171). Infrarenal and ascending aortic diameters were measured by preoperative computed tomography and corrected for body surface area. Results: Infrarenal and ascending aortic diameters were significantly shorter in the DM+ group than in the DM- group (21.3±5.0mm vs. 24.7±9.8mm, p<0.001 and 36.0±4.4mm vs. 37.8±5.5mm, p=0.001, respectively). The rates of infrarenal aortic diameter ≥30mm and ascending aortic diameter ≥40mm were significantly lower in the DM+ group than in the DM- group (3.5% vs. 13.3%, p=0.003 and 14.2% vs. 24.1%, p=0.025, respectively). Multivariate models demonstrated diabetes to be an independent predictor of both infrarenal and ascending aortic diameters even after correction for body surface area. Conclusion: Our findings indicated an inverse association between diabetes and aortic dilatation of both the infrarenal and ascending aorta in patients with advanced coronary artery disease.
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U2 - 10.1016/j.atherosclerosis.2015.07.016
DO - 10.1016/j.atherosclerosis.2015.07.016
M3 - Article
C2 - 26188534
AN - SCOPUS:84937042494
SN - 0021-9150
VL - 242
SP - 123
EP - 127
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -