Investigation of morphological and functional changes in the small intestine with pancreatic disease

Yosuke Nakamura, Akihiro Itoh, Hiroki Kawashima, Eizaburo Ohno, Yuya Itoh, Takeshi Hiramatsu, Hiroyuki Sugimoto, Hajime Sumi, Daijuro Hayashi, Takamichi Kuwahara, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Naoki Omiya, Yoshiaki Katano, Masatoshi Ishigami, Yoshie Shimoyama, Shigeo Nakamura, Hidemi Goto, Yoshiki Hirooka

研究成果: Article

2 引用 (Scopus)

抄録

Objectives: The aim of this study was to investigate the relationship between pancreas and small intestine evaluating the endoscopic and histopathologic findings of the proximal small intestine in pancreatic diseases. Methods: Fifty patients (18 patientswith chronic pancreatitis, 17 patients with pancreatic cancer, 15 control subjects) underwent enteroscopy using a prototype enteroscope. The villous height of the jejunum on bioptic specimens was measured, and the mean values of the villi were compared among the 3 groups. Exocrine function was calculated by the pancreatic function diagnostic test, and the correlation between the recovery rate of p-aminobenzoic acid and the villous height was assessed. Finally, the distribution of the K cells secreting glucose-dependent insulinotropic polypeptide and the L cells secreting glucagon-like peptide 1 in the duodenum and jejunum was investigated using immunohistochemistry for glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1. Results: The mean villous height in chronic pancreatitis (328 ± 67 μm) was significantly lower than that in pancreatic cancer (413 ± 57 μm) and control subjects (461 ± 97 μm) (P = 0.004 and P < 0.0001, respectively). A positive correlation was found between the recovery rate of p-aminobenzoic acid and the villous height (r = 0.52, P = 0.0001). The presence of K and L cells was verified in the duodenum and the jejunum. Conclusions: Close relationship between pancreas and small intestine was demonstrated.

元の言語English
ページ(範囲)1352-1357
ページ数6
ジャーナルPancreas
44
発行部数8
DOI
出版物ステータスPublished - 01-01-2015
外部発表Yes

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Pancreatic Diseases
Jejunum
Small Intestine
4-Aminobenzoic Acid
Glucagon-Like Peptide 1
Chronic Pancreatitis
Pancreatic Neoplasms
Duodenum
Pancreas
Pancreatic Function Tests
Glucose
Peptides
Routine Diagnostic Tests
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

これを引用

Nakamura, Y., Itoh, A., Kawashima, H., Ohno, E., Itoh, Y., Hiramatsu, T., ... Hirooka, Y. (2015). Investigation of morphological and functional changes in the small intestine with pancreatic disease. Pancreas, 44(8), 1352-1357. https://doi.org/10.1097/MPA.0000000000000426
Nakamura, Yosuke ; Itoh, Akihiro ; Kawashima, Hiroki ; Ohno, Eizaburo ; Itoh, Yuya ; Hiramatsu, Takeshi ; Sugimoto, Hiroyuki ; Sumi, Hajime ; Hayashi, Daijuro ; Kuwahara, Takamichi ; Funasaka, Kohei ; Nakamura, Masanao ; Miyahara, Ryoji ; Omiya, Naoki ; Katano, Yoshiaki ; Ishigami, Masatoshi ; Shimoyama, Yoshie ; Nakamura, Shigeo ; Goto, Hidemi ; Hirooka, Yoshiki. / Investigation of morphological and functional changes in the small intestine with pancreatic disease. :: Pancreas. 2015 ; 巻 44, 番号 8. pp. 1352-1357.
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abstract = "Objectives: The aim of this study was to investigate the relationship between pancreas and small intestine evaluating the endoscopic and histopathologic findings of the proximal small intestine in pancreatic diseases. Methods: Fifty patients (18 patientswith chronic pancreatitis, 17 patients with pancreatic cancer, 15 control subjects) underwent enteroscopy using a prototype enteroscope. The villous height of the jejunum on bioptic specimens was measured, and the mean values of the villi were compared among the 3 groups. Exocrine function was calculated by the pancreatic function diagnostic test, and the correlation between the recovery rate of p-aminobenzoic acid and the villous height was assessed. Finally, the distribution of the K cells secreting glucose-dependent insulinotropic polypeptide and the L cells secreting glucagon-like peptide 1 in the duodenum and jejunum was investigated using immunohistochemistry for glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1. Results: The mean villous height in chronic pancreatitis (328 ± 67 μm) was significantly lower than that in pancreatic cancer (413 ± 57 μm) and control subjects (461 ± 97 μm) (P = 0.004 and P < 0.0001, respectively). A positive correlation was found between the recovery rate of p-aminobenzoic acid and the villous height (r = 0.52, P = 0.0001). The presence of K and L cells was verified in the duodenum and the jejunum. Conclusions: Close relationship between pancreas and small intestine was demonstrated.",
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Nakamura, Y, Itoh, A, Kawashima, H, Ohno, E, Itoh, Y, Hiramatsu, T, Sugimoto, H, Sumi, H, Hayashi, D, Kuwahara, T, Funasaka, K, Nakamura, M, Miyahara, R, Omiya, N, Katano, Y, Ishigami, M, Shimoyama, Y, Nakamura, S, Goto, H & Hirooka, Y 2015, 'Investigation of morphological and functional changes in the small intestine with pancreatic disease', Pancreas, 巻. 44, 番号 8, pp. 1352-1357. https://doi.org/10.1097/MPA.0000000000000426

Investigation of morphological and functional changes in the small intestine with pancreatic disease. / Nakamura, Yosuke; Itoh, Akihiro; Kawashima, Hiroki; Ohno, Eizaburo; Itoh, Yuya; Hiramatsu, Takeshi; Sugimoto, Hiroyuki; Sumi, Hajime; Hayashi, Daijuro; Kuwahara, Takamichi; Funasaka, Kohei; Nakamura, Masanao; Miyahara, Ryoji; Omiya, Naoki; Katano, Yoshiaki; Ishigami, Masatoshi; Shimoyama, Yoshie; Nakamura, Shigeo; Goto, Hidemi; Hirooka, Yoshiki.

:: Pancreas, 巻 44, 番号 8, 01.01.2015, p. 1352-1357.

研究成果: Article

TY - JOUR

T1 - Investigation of morphological and functional changes in the small intestine with pancreatic disease

AU - Nakamura, Yosuke

AU - Itoh, Akihiro

AU - Kawashima, Hiroki

AU - Ohno, Eizaburo

AU - Itoh, Yuya

AU - Hiramatsu, Takeshi

AU - Sugimoto, Hiroyuki

AU - Sumi, Hajime

AU - Hayashi, Daijuro

AU - Kuwahara, Takamichi

AU - Funasaka, Kohei

AU - Nakamura, Masanao

AU - Miyahara, Ryoji

AU - Omiya, Naoki

AU - Katano, Yoshiaki

AU - Ishigami, Masatoshi

AU - Shimoyama, Yoshie

AU - Nakamura, Shigeo

AU - Goto, Hidemi

AU - Hirooka, Yoshiki

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objectives: The aim of this study was to investigate the relationship between pancreas and small intestine evaluating the endoscopic and histopathologic findings of the proximal small intestine in pancreatic diseases. Methods: Fifty patients (18 patientswith chronic pancreatitis, 17 patients with pancreatic cancer, 15 control subjects) underwent enteroscopy using a prototype enteroscope. The villous height of the jejunum on bioptic specimens was measured, and the mean values of the villi were compared among the 3 groups. Exocrine function was calculated by the pancreatic function diagnostic test, and the correlation between the recovery rate of p-aminobenzoic acid and the villous height was assessed. Finally, the distribution of the K cells secreting glucose-dependent insulinotropic polypeptide and the L cells secreting glucagon-like peptide 1 in the duodenum and jejunum was investigated using immunohistochemistry for glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1. Results: The mean villous height in chronic pancreatitis (328 ± 67 μm) was significantly lower than that in pancreatic cancer (413 ± 57 μm) and control subjects (461 ± 97 μm) (P = 0.004 and P < 0.0001, respectively). A positive correlation was found between the recovery rate of p-aminobenzoic acid and the villous height (r = 0.52, P = 0.0001). The presence of K and L cells was verified in the duodenum and the jejunum. Conclusions: Close relationship between pancreas and small intestine was demonstrated.

AB - Objectives: The aim of this study was to investigate the relationship between pancreas and small intestine evaluating the endoscopic and histopathologic findings of the proximal small intestine in pancreatic diseases. Methods: Fifty patients (18 patientswith chronic pancreatitis, 17 patients with pancreatic cancer, 15 control subjects) underwent enteroscopy using a prototype enteroscope. The villous height of the jejunum on bioptic specimens was measured, and the mean values of the villi were compared among the 3 groups. Exocrine function was calculated by the pancreatic function diagnostic test, and the correlation between the recovery rate of p-aminobenzoic acid and the villous height was assessed. Finally, the distribution of the K cells secreting glucose-dependent insulinotropic polypeptide and the L cells secreting glucagon-like peptide 1 in the duodenum and jejunum was investigated using immunohistochemistry for glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1. Results: The mean villous height in chronic pancreatitis (328 ± 67 μm) was significantly lower than that in pancreatic cancer (413 ± 57 μm) and control subjects (461 ± 97 μm) (P = 0.004 and P < 0.0001, respectively). A positive correlation was found between the recovery rate of p-aminobenzoic acid and the villous height (r = 0.52, P = 0.0001). The presence of K and L cells was verified in the duodenum and the jejunum. Conclusions: Close relationship between pancreas and small intestine was demonstrated.

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Nakamura Y, Itoh A, Kawashima H, Ohno E, Itoh Y, Hiramatsu T その他. Investigation of morphological and functional changes in the small intestine with pancreatic disease. Pancreas. 2015 1 1;44(8):1352-1357. https://doi.org/10.1097/MPA.0000000000000426