Involvement of BDNF receptor TrkB in spatial memory formation

Makoto Mizuno, Kiyofumi Yamada, Jue He, Akira Nakajima, Toshitaka Nabeshima

研究成果: Article

131 引用 (Scopus)

抜粋

The N-methyl-D-aspartate (NMDA) receptors are involved in long-term potentiation (LTP), and are phosphorylated by several tyrosine kinases including a Src-family tyrosine kinase Fyn. Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which also enhances hippocampal synaptic transmission and efficacy by increasing NMDA receptor activity. Here, we show that Fyn is a key molecule linking the BDNF receptor TrkB with NMDA receptors, which play an important role in spatial memory formation in a radial arm maze. Spatial learning induced phosphorylation of TrkB, Fyn, and NR2B, but not NR2A, in the hippocampus. Fyn was coimmunoprecipitated with TrkB and NR2B, and this association was increased in well-trained rats compared with control animals. Continuous intracerebroventricular infusion of PP2, a tyrosine kinase inhibitor, in rats delayed memory acquisition in the radial arm maze, but PP2-treated animals reached the same level of learning as the controls. The phosphorylation of Fyn and NR2B, but not TrkB, was diminished by PP2 treatment. Our findings suggest the importance of interaction between BDNF/TrkB signaling and NMDA receptors for spatial memory in the hippocampus.

元の言語English
ページ(範囲)108-115
ページ数8
ジャーナルLearning and Memory
10
発行部数2
DOI
出版物ステータスPublished - 01-03-2003
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

これを引用

Mizuno, M., Yamada, K., He, J., Nakajima, A., & Nabeshima, T. (2003). Involvement of BDNF receptor TrkB in spatial memory formation. Learning and Memory, 10(2), 108-115. https://doi.org/10.1101/lm.56003